Southern Illinois 31-30 Western Illinois 2021-10-02 20:00
Stadium: Hanson Field Round: 1
Home Manager: Jared Elliott Away Manager: Nick Hill
Head to Head
| NCAAF | 2019/11/16 19:00 | SO Illinois v Western Illinois | W | 45-21 |
| NCAAF FCS | 2018/11/03 18:00 | Western Illinois v SO Illinois | L | 34-31 |
| NCAAF | 2017/11/18 19:00 | Western Illinois v SO Illinois | L | 28-14 |
Home History
| NCAAF | 2021/09/25 19:00 | Illinois State v SO Illinois | W | 17-35 |
| NCAAF | 2021/09/18 23:00 | Dayton v SO Illinois | W | 3-55 |
| NCAAF | 2021/09/11 23:00 | SO Illinois v Kansas State | L | 23-31 |
| NCAAF | 2021/09/02 23:30 | SO Illinois v SE Missouri St | W | 47-21 |
| NCAAF | 2021/05/03 01:00 | SO Illinois v South Dakota State | L | 26-31 |
| NCAAF | 2021/04/24 20:00 | SO Illinois v Weber State | W | 34-31 |
| NCAAF | 2021/04/17 17:00 | SE Louisiana v SO Illinois | W | 48-55 |
| NCAAF | 2021/03/27 19:00 | SO Illinois v Missouri St | L | 27-30 |
Away History
| NCAAF | 2021/09/25 22:00 | Western Illinois v Youngstown State | W | 38-35 |
| NCAAF | 2021/09/18 20:00 | East Washington v Western Illinois | L | 62-56 |
| NCAAF | 2021/09/12 00:00 | Western Illinois v Montana | L | 7-42 |
| NCAAF | 2021/09/02 23:00 | Western Illinois v Ball State | L | 21-31 |
| NCAAF | 2021/04/04 00:00 | Youngstown State v Western Illinois | W | 24-27 |
| NCAAF | 2021/03/27 16:00 | Northern Iowa v Western Illinois | L | 34-20 |
| NCAAF | 2021/03/20 16:00 | Western Illinois v Illinois State | L | 18-26 |
| NCAAF | 2021/03/13 18:00 | North Dakota v Western Illinois | L | 38-21 |