[12] Southampton 0-6 Chelsea [3] 2022-04-09 14:00
Stadium: St. Mary's Stadium Round: 32
Referee: Kevin Friend Home Manager: Ralph Hasenhuttl Away Manager: Thomas Tuchel
Head to Head
| England EFL Cup | 2021/10/26 18:45 | Chelsea v Southampton | L | 5-4 |
| England Premier League | 2021/10/02 14:00 | Chelsea v Southampton | L | 3-1 |
| England Premier League | 2021/02/20 12:30 | Southampton v Chelsea | D | 1-1 |
| England Premier League | 2020/10/17 14:00 | Chelsea v Southampton | D | 3-3 |
| England Premier League | 2019/12/26 15:00 | Chelsea v Southampton | W | 0-2 |
| England Premier League | 2019/10/06 13:00 | Southampton v Chelsea | L | 1-4 |
| England Premier League | 2019/01/02 19:45 | Chelsea v Southampton | D | 0-0 |
| England Premier League | 2018/10/07 13:15 | Southampton v Chelsea | L | 0-3 |
Home History
| England Premier League | 2022/04/02 14:00 | Leeds v Southampton | D | 1-1 |
| England FA Cup | 2022/03/20 15:00 | Southampton v Man City | L | 1-4 |
| England Premier League | 2022/03/13 14:00 | Southampton v Watford | L | 1-2 |
| England Premier League | 2022/03/10 19:30 | Southampton v Newcastle | L | 1-2 |
| England Premier League | 2022/03/05 15:00 | Aston Villa v Southampton | L | 4-0 |
| England FA Cup | 2022/03/02 19:30 | Southampton v West Ham | W | 3-1 |
| England Premier League | 2022/02/25 20:00 | Southampton v Norwich | W | 2-0 |
| England Premier League | 2022/02/19 15:00 | Southampton v Everton | W | 2-0 |
Away History
| UEFA Champions League | 2022/04/06 19:00 | Chelsea v Real Madrid | L | 1-3 |
| England Premier League | 2022/04/02 14:00 | Chelsea v Brentford | L | 1-4 |
| England FA Cup | 2022/03/19 17:15 | Middlesbrough v Chelsea | W | 0-2 |
| UEFA Champions League | 2022/03/16 20:00 | Lille v Chelsea | W | 1-2 |
| England Premier League | 2022/03/13 14:00 | Chelsea v Newcastle | W | 1-0 |
| England Premier League | 2022/03/10 19:30 | Norwich v Chelsea | W | 1-3 |
| England Premier League | 2022/03/05 15:00 | Burnley v Chelsea | W | 0-4 |
| England FA Cup | 2022/03/02 19:15 | Luton v Chelsea | W | 2-3 |