[12] Southampton 0-6 Chelsea [3] 2022-04-09 14:00
Stadium: St. Mary's Stadium Round: 32
Referee: Kevin Friend Home Manager: Ralph Hasenhuttl Away Manager: Thomas Tuchel
Head to Head
| England EFL Cup | 2021/10/26 18:45 | Chelsea v Southampton | L | 5-4 |
| England Premier League | 2021/10/02 14:00 | Chelsea v Southampton | L | 3-1 |
| England Premier League | 2021/02/20 12:30 | Southampton v Chelsea | D | 1-1 |
| England Premier League | 2020/10/17 14:00 | Chelsea v Southampton | D | 3-3 |
| England Premier League | 2019/12/26 15:00 | Chelsea v Southampton | W | 0-2 |
| England Premier League | 2019/10/06 13:00 | Southampton v Chelsea | L | 1-4 |
| England Premier League | 2019/01/02 19:45 | Chelsea v Southampton | D | 0-0 |
| England Premier League | 2018/10/07 13:15 | Southampton v Chelsea | L | 0-3 |
| England FA Cup | 2018/04/22 14:00 | Chelsea v Southampton | L | 2-0 |
| England Premier League | 2018/04/14 11:30 | Southampton v Chelsea | L | 2-3 |
| England Premier League | 2017/12/16 15:00 | Chelsea v Southampton | L | 1-0 |
| England Premier League | 2017/04/25 18:45 | Chelsea v Southampton | L | 4-2 |
| England Premier League | 2016/10/30 16:00 | Southampton v Chelsea | L | 0-2 |
| England Premier League | 2016/02/27 15:00 | Southampton v Chelsea | L | 1-2 |
| England Premier League | 2015/10/03 16:30 | Chelsea v Southampton | W | 1-3 |
| England Premier League | 2015/03/15 13:30 | Chelsea v Southampton | D | 1-1 |
| England Premier League | 2014/12/28 14:05 | Southampton v Chelsea | D | 1-1 |