[15] Real Potosi 3-0 Real Santa Cruz [10] 2021-09-21 23:00
Stadium: Estadio Victor Agustín Ugarte Round: 20
Head to Head
| Bolivia Apertura | 2021/05/12 19:00 | Real Santa Cruz v Real Potosi | L | 4-1 |
| Bolivia Apertura | 2020/12/09 19:00 | Real Santa Cruz v Real Potosi | L | 3-1 |
| Bolivia Apertura | 2020/02/02 21:15 | Real Potosi v Real Santa Cruz | W | 2-1 |
Home History
| Bolivia Apertura | 2021/09/17 19:00 | San Jose v Real Potosi | D | 0-0 |
| Bolivia Apertura | 2021/09/12 19:00 | Real Potosi v Real Tomayapo | W | 1-0 |
| Bolivia Apertura | 2021/08/23 23:00 | Club Aurora v Real Potosi | L | 5-0 |
| Bolivia Apertura | 2021/08/19 22:15 | Real Potosi v Bolivar | L | 0-2 |
| Bolivia Apertura | 2021/08/13 23:30 | Real Potosi v Blooming | W | 3-1 |
| Bolivia Apertura | 2021/08/09 19:00 | Guabira v Real Potosi | L | 3-0 |
| Bolivia Apertura | 2021/08/04 00:30 | Independiente Petrolero v Real Potosi | L | 2-1 |
| Bolivia Apertura | 2021/07/30 22:15 | Real Potosi v Royal Pari FC | L | 1-3 |
Away History
| Bolivia Apertura | 2021/09/18 19:00 | Real Santa Cruz v Royal Pari FC | W | 2-1 |
| Bolivia Apertura | 2021/09/14 19:00 | Always Ready v Real Santa Cruz | L | 4-0 |
| Bolivia Apertura | 2021/08/23 19:00 | Real Santa Cruz v Atletico Palmaflor Vinto | W | 1-0 |
| Bolivia Apertura | 2021/08/20 00:15 | Jorge Wilstermann v Real Santa Cruz | L | 5-1 |
| Bolivia Apertura | 2021/08/14 23:30 | The Strongest v Real Santa Cruz | W | 1-2 |
| Bolivia Apertura | 2021/08/07 19:00 | Real Santa Cruz v Oriente Petrolero | D | 0-0 |
| Bolivia Apertura | 2021/08/03 22:15 | Nacional Potosi v Real Santa Cruz | D | 2-2 |
| Bolivia Apertura | 2021/07/31 19:00 | Real Santa Cruz v Independiente Petrolero | W | 2-0 |