[15] Real Potosi 3-0 Real Santa Cruz [10] 2021-09-21 23:00
Stadium: Estadio Victor Agustín Ugarte Round: 20
Head to Head
| Bolivia Apertura | 2021/05/12 19:00 | Real Santa Cruz v Real Potosi | L | 4-1 |
| Bolivia Apertura | 2020/12/09 19:00 | Real Santa Cruz v Real Potosi | L | 3-1 |
| Bolivia Apertura | 2020/02/02 21:15 | Real Potosi v Real Santa Cruz | W | 2-1 |