[5] VAN Canucks 2-5 BUF Sabres [7] 2021-10-19 23:00
Stadium: KeyBank Center
Home Manager: Don Granato Away Manager: Travis Green
Head to Head
| NHL | 2020/01/11 18:00 | VAN Canucks v BUF Sabres | W | 6-3 |
| NHL | 2019/12/07 21:00 | BUF Sabres v VAN Canucks | W | 5-6 |
| NHL | 2019/01/19 03:00 | BUF Sabres v VAN Canucks | W | 3-4 |
| NHL | 2018/11/10 18:00 | VAN Canucks v BUF Sabres | L | 3-4 |
| NHL | 2018/01/26 03:00 | BUF Sabres v VAN Canucks | L | 4-0 |
| NHL | 2017/10/20 23:00 | VAN Canucks v BUF Sabres | W | 4-2 |
| NHL | 2017/02/13 00:30 | VAN Canucks v BUF Sabres | W | 4-2 |
| NHL | 2016/10/21 02:00 | BUF Sabres v VAN Canucks | W | 1-2 |
Home History
| NHL | 2021/10/16 23:00 | VAN Canucks v DET Red Wings | L | 1-3 |
| NHL | 2021/10/15 23:00 | VAN Canucks v PHI Flyers | W | 5-4 |
| NHL | 2021/10/14 02:00 | VAN Canucks v EDM Oilers | L | 2-3 |
| NHL Pre-Season | 2021/10/10 01:00 | EDM Oilers v VAN Canucks | L | 3-2 |
| NHL Pre-Season | 2021/10/08 01:00 | VAN Canucks v EDM Oilers | L | 2-3 |
| NHL Pre-Season | 2021/10/06 02:00 | SEA Kraken v VAN Canucks | L | 4-0 |
| NHL Pre-Season | 2021/10/03 23:00 | WIN Jets v VAN Canucks | W | 2-3 |
| NHL Pre-Season | 2021/10/02 01:00 | VAN Canucks v CAL Flames | L | 1-4 |
Away History
| NHL | 2021/10/16 17:00 | ARZ Coyotes v BUF Sabres | W | 1-2 |
| NHL | 2021/10/14 23:00 | MON Canadiens v BUF Sabres | W | 1-5 |
| NHL Pre-Season | 2021/10/09 19:00 | DET Red Wings v BUF Sabres | W | 1-3 |
| NHL Pre-Season | 2021/10/05 23:00 | BUF Sabres v PIT Penguins | L | 4-5 |
| NHL Pre-Season | 2021/10/04 23:00 | CLB Blue Jackets v BUF Sabres | L | 5-3 |
| NHL Pre-Season | 2021/10/01 23:00 | PIT Penguins v BUF Sabres | L | 2-1 |
| NHL Pre-Season | 2021/09/30 23:30 | BUF Sabres v DET Red Wings | L | 2-6 |
| NHL Pre-Season | 2021/09/28 23:00 | BUF Sabres v CLB Blue Jackets | W | 5-4 |