[3] BUF Sabres 3-5 SJ Sharks [3] 2021-11-03 02:30
Stadium: SAP Center at San Jose
Home Manager: Bob Boughner Away Manager: Don Granato
Head to Head
| NHL | 2019/10/22 23:00 | SJ Sharks v BUF Sabres | W | 3-4 |
| NHL | 2019/10/20 02:30 | BUF Sabres v SJ Sharks | W | 4-3 |
| NHL | 2018/11/28 00:00 | SJ Sharks v BUF Sabres | W | 2-3 |
| NHL | 2018/10/19 02:30 | BUF Sabres v SJ Sharks | L | 1-5 |
| NHL | 2017/10/28 17:00 | SJ Sharks v BUF Sabres | L | 3-2 |
| NHL | 2017/10/13 02:30 | BUF Sabres v SJ Sharks | L | 2-3 |
| NHL | 2017/03/15 02:30 | BUF Sabres v SJ Sharks | L | 1-4 |
| NHL | 2017/02/08 00:00 | SJ Sharks v BUF Sabres | W | 4-5 |
Home History
| NHL | 2021/10/31 20:00 | BUF Sabres v LA Kings | L | 2-3 |
| NHL | 2021/10/29 02:00 | BUF Sabres v ANA Ducks | W | 4-3 |
| NHL | 2021/10/25 23:00 | TB Lightning v BUF Sabres | W | 1-5 |
| NHL | 2021/10/23 23:00 | BUF Sabres v NJ Devils | L | 1-2 |
| NHL | 2021/10/22 23:00 | BOS Bruins v BUF Sabres | L | 4-1 |
| NHL | 2021/10/19 23:00 | VAN Canucks v BUF Sabres | W | 2-5 |
| NHL | 2021/10/16 17:00 | ARZ Coyotes v BUF Sabres | W | 1-2 |
| NHL | 2021/10/14 23:00 | MON Canadiens v BUF Sabres | W | 1-5 |
Away History
| NHL | 2021/10/30 23:00 | WIN Jets v SJ Sharks | W | 1-2 |
| NHL | 2021/10/29 02:30 | MON Canadiens v SJ Sharks | L | 4-0 |
| NHL | 2021/10/27 00:30 | SJ Sharks v NAS Predators | L | 1-3 |
| NHL | 2021/10/24 17:00 | SJ Sharks v BOS Bruins | L | 3-4 |
| NHL | 2021/10/22 22:00 | SJ Sharks v TOR Maple Leafs | W | 5-3 |
| NHL | 2021/10/21 23:00 | SJ Sharks v OTT Senators | W | 2-1 |
| NHL | 2021/10/19 23:00 | SJ Sharks v MON Canadiens | W | 5-0 |
| NHL | 2021/10/17 02:00 | WIN Jets v SJ Sharks | W | 3-4 |