[52] Boston College 14-28 Louisville [74] 2021-10-23 20:00
Stadium: L&N Federal Credit Union Stadium Round: 1
Home Manager: Scott Satterfield Away Manager: Jeff Hafley
Head to Head
| NCAAF | 2020/11/28 21:00 | Louisville v Boston College | W | 27-34 |
| NCAAF | 2019/10/05 16:30 | Boston College v Louisville | L | 39-41 |
| NCAAF | 2018/10/13 16:30 | Louisville v Boston College | W | 20-38 |
| NCAAF | 2017/10/14 16:20 | Boston College v Louisville | W | 45-42 |
| NCAAF | 2016/11/05 16:00 | Louisville v Boston College | L | 52-7 |
| NCAAF | 2015/10/24 16:30 | Louisville v Boston College | L | 17-14 |
| NCAAF | 2014/11/09 00:15 | Boston College v Louisville | L | 19-38 |
Home History
| NCAAF | 2021/10/16 23:30 | NC State v Boston College | L | 33-7 |
| NCAAF | 2021/10/02 23:30 | Boston College v Clemson | L | 13-19 |
| NCAAF | 2021/09/25 16:00 | Missouri v Boston College | W | 34-41 |
| NCAAF | 2021/09/18 16:00 | Boston College v Temple | W | 28-3 |
| NCAAF | 2021/09/11 19:30 | Boston College v Massachusetts | W | 45-28 |
| NCAAF | 2021/09/04 16:00 | Colgate v Boston College | W | 0-51 |
| NCAAF | 2020/12/05 20:30 | Boston College v Virginia | L | 32-43 |
| NCAAF | 2020/11/28 21:00 | Louisville v Boston College | W | 27-34 |
Away History
| NCAAF | 2021/10/09 19:00 | Virginia v Louisville | L | 34-33 |
| NCAAF | 2021/10/02 16:30 | Louisville v Wake Forest | L | 34-37 |
| NCAAF | 2021/09/25 19:30 | Louisville v Florida State | W | 31-23 |
| NCAAF | 2021/09/17 23:30 | Central Florida v Louisville | W | 35-42 |
| NCAAF | 2021/09/11 23:00 | Eastern Kentucky v Louisville | W | 3-30 |
| NCAAF | 2021/09/07 00:00 | Louisville v Mississippi | L | 24-43 |
| NCAAF | 2020/12/12 17:00 | Wake Forest v Louisville | W | 21-45 |
| NCAAF | 2020/11/28 21:00 | Louisville v Boston College | L | 27-34 |