[52] Boston College 14-28 Louisville [74] 2021-10-23 20:00
Stadium: L&N Federal Credit Union Stadium Round: 1
Home Manager: Scott Satterfield Away Manager: Jeff Hafley
Head to Head
| NCAAF | 2020/11/28 21:00 | Louisville v Boston College | W | 27-34 |
| NCAAF | 2019/10/05 16:30 | Boston College v Louisville | L | 39-41 |
| NCAAF | 2018/10/13 16:30 | Louisville v Boston College | W | 20-38 |
| NCAAF | 2017/10/14 16:20 | Boston College v Louisville | W | 45-42 |
| NCAAF | 2016/11/05 16:00 | Louisville v Boston College | L | 52-7 |
| NCAAF | 2015/10/24 16:30 | Louisville v Boston College | L | 17-14 |
| NCAAF | 2014/11/09 00:15 | Boston College v Louisville | L | 19-38 |