[76] East Carolina 24-31 Houston [22] 2021-10-24 01:20
Stadium: Space City Financial Stadium Round: 1
Home Manager: Dana Holgorsen Away Manager: Mike Houston
Head to Head
| NCAAF | 2018/10/13 23:00 | Houston v East Carolina | L | 42-20 |
| NCAAF | 2017/11/04 16:00 | East Carolina v Houston | L | 27-52 |
| NCAAF | 2012/11/03 12:00 | East Carolina v Houston | W | 48-28 |
| NCAAF | 2011/10/08 12:00 | Houston v East Carolina | L | 56-3 |
| NCAAF | 2009/12/05 12:00 | East Carolina v Houston | W | 38-32 |
| NCAAF | 2008/09/27 12:00 | East Carolina v Houston | L | 24-41 |
| NCAAF | 2007/09/29 12:00 | Houston v East Carolina | W | 35-37 |
| NCAAF | 2004/11/06 12:00 | Houston v East Carolina | L | 34-24 |
Home History
| NCAAF | 2021/10/09 22:00 | East Carolina v Central Florida | L | 16-20 |
| NCAAF | 2021/10/02 19:30 | Tulane v East Carolina | W | 29-52 |
| NCAAF | 2021/09/25 22:00 | Charleston Southern v East Carolina | W | 28-31 |
| NCAAF | 2021/09/18 22:00 | East Carolina v Marshall | W | 42-38 |
| NCAAF | 2021/09/11 16:00 | South Carolina v East Carolina | L | 20-17 |
| NCAAF | 2021/09/02 23:30 | East Carolina v Appalachian St | L | 19-33 |
| NCAAF | 2020/11/28 17:00 | SMU v East Carolina | W | 38-52 |
| NCAAF | 2020/11/21 17:00 | East Carolina v Temple | W | 28-3 |
Away History
| NCAAF | 2021/10/07 23:30 | Houston v Tulane | W | 40-22 |
| NCAAF | 2021/10/01 23:30 | Houston v Tulsa | W | 45-10 |
| NCAAF | 2021/09/25 23:00 | Navy v Houston | W | 20-28 |
| NCAAF | 2021/09/18 23:00 | Grambling State v Houston | W | 0-45 |
| NCAAF | 2021/09/11 22:30 | Houston v Rice | W | 44-7 |
| NCAAF | 2021/09/04 23:00 | Texas Tech v Houston | L | 38-21 |
| NCAAF | 2020/12/24 20:30 | Hawaii v Houston | L | 28-14 |
| NCAAF | 2020/12/12 20:45 | Houston v Memphis | L | 27-30 |