[76] East Carolina 24-31 Houston [22] 2021-10-24 01:20
Stadium: Space City Financial Stadium Round: 1
Home Manager: Dana Holgorsen Away Manager: Mike Houston
Head to Head
| NCAAF | 2018/10/13 23:00 | Houston v East Carolina | L | 42-20 |
| NCAAF | 2017/11/04 16:00 | East Carolina v Houston | L | 27-52 |
| NCAAF | 2012/11/03 12:00 | East Carolina v Houston | W | 48-28 |
| NCAAF | 2011/10/08 12:00 | Houston v East Carolina | L | 56-3 |
| NCAAF | 2009/12/05 12:00 | East Carolina v Houston | W | 38-32 |
| NCAAF | 2008/09/27 12:00 | East Carolina v Houston | L | 24-41 |
| NCAAF | 2007/09/29 12:00 | Houston v East Carolina | W | 35-37 |
| NCAAF | 2004/11/06 12:00 | Houston v East Carolina | L | 34-24 |
| NCAAF | 2003/09/30 12:00 | East Carolina v Houston | L | 13-27 |
| NCAAF | 2002/11/09 12:00 | Houston v East Carolina | W | 48-54 |
| NCAAF | 2000/11/11 12:00 | East Carolina v Houston | W | 62-20 |