[6] Michigan State 29-40 Purdue [51] 2021-11-06 19:30
Stadium: Ross-Ade Stadium Round: 1
Home Manager: Jeff Brohm Away Manager: Melvin Tucker
Head to Head
| NCAAF | 2018/10/27 16:00 | Purdue v Michigan State | W | 13-23 |
| NCAAF | 2015/10/03 16:00 | Michigan State v Purdue | W | 24-21 |
| NCAAF | 2014/10/11 19:30 | Purdue v Michigan State | W | 31-45 |
| NCAAF | 2010/11/20 12:00 | Michigan State v Purdue | W | 35-31 |
| NCAAF | 2009/11/14 12:00 | Purdue v Michigan State | W | 37-40 |
| NCAAF | 2008/11/08 12:00 | Michigan State v Purdue | W | 21-7 |
| NCAAF | 2007/11/10 12:00 | Purdue v Michigan State | W | 31-48 |
| NCAAF | 2006/11/04 12:00 | Michigan State v Purdue | L | 15-17 |
Home History
| NCAAF | 2021/10/30 16:00 | Michigan v Michigan State | W | 33-37 |
| NCAAF | 2021/10/16 16:00 | Michigan State v Indiana | W | 20-15 |
| NCAAF | 2021/10/09 16:00 | Michigan State v Rutgers | W | 31-13 |
| NCAAF | 2021/10/02 23:30 | Western Kentucky v Michigan State | W | 31-48 |
| NCAAF | 2021/09/25 23:00 | Nebraska v Michigan State | W | 20-23 |
| NCAAF | 2021/09/18 16:00 | Michigan State v Miami Florida | W | 38-17 |
| NCAAF | 2021/09/11 16:00 | Youngstown State v Michigan State | W | 14-42 |
| NCAAF | 2021/09/04 01:00 | Michigan State v Northwestern | W | 38-21 |
Away History
| NCAAF | 2021/10/30 19:30 | Purdue v Nebraska | W | 28-23 |
| NCAAF | 2021/10/23 19:00 | Wisconsin v Purdue | L | 30-13 |
| NCAAF | 2021/10/16 19:30 | Purdue v Iowa | W | 24-7 |
| NCAAF | 2021/10/02 16:00 | Minnesota v Purdue | L | 20-13 |
| NCAAF | 2021/09/25 19:30 | Illinois v Purdue | W | 9-13 |
| NCAAF | 2021/09/18 18:30 | Purdue v Notre Dame | L | 13-27 |
| NCAAF | 2021/09/11 19:00 | Purdue v Connecticut | W | 49-0 |
| NCAAF | 2021/09/04 23:00 | Oregon State v Purdue | W | 21-30 |