[6] Michigan State 29-40 Purdue [51] 2021-11-06 19:30
Stadium: Ross-Ade Stadium Round: 1
Home Manager: Jeff Brohm Away Manager: Melvin Tucker
Head to Head
| NCAAF | 2018/10/27 16:00 | Purdue v Michigan State | W | 13-23 |
| NCAAF | 2015/10/03 16:00 | Michigan State v Purdue | W | 24-21 |
| NCAAF | 2014/10/11 19:30 | Purdue v Michigan State | W | 31-45 |
| NCAAF | 2010/11/20 12:00 | Michigan State v Purdue | W | 35-31 |
| NCAAF | 2009/11/14 12:00 | Purdue v Michigan State | W | 37-40 |
| NCAAF | 2008/11/08 12:00 | Michigan State v Purdue | W | 21-7 |
| NCAAF | 2007/11/10 12:00 | Purdue v Michigan State | W | 31-48 |
| NCAAF | 2006/11/04 12:00 | Michigan State v Purdue | L | 15-17 |
| NCAAF | 2005/11/05 12:00 | Purdue v Michigan State | L | 28-21 |
| NCAAF | 2002/11/16 12:00 | Michigan State v Purdue | L | 42-45 |
| NCAAF | 2001/11/17 12:00 | Purdue v Michigan State | L | 24-14 |
| NCAAF | 2000/11/11 12:00 | Michigan State v Purdue | W | 30-10 |