[52] Clemson 30-24 Louisville [81] 2021-11-06 23:30
Stadium: L&N Federal Credit Union Stadium Round: 1
Home Manager: Scott Satterfield Away Manager: Dabo Swinney
Head to Head
| NCAAF | 2019/10/19 16:00 | Clemson v Louisville | W | 45-10 |
| NCAAF | 2018/11/03 16:00 | Louisville v Clemson | W | 16-77 |
| NCAAF | 2017/09/17 00:00 | Clemson v Louisville | W | 47-21 |
| NCAAF | 2016/10/02 00:00 | Louisville v Clemson | W | 36-42 |
| NCAAF | 2015/09/17 23:30 | Louisville v Clemson | W | 17-20 |
| NCAAF | 2014/10/11 19:30 | Clemson v Louisville | W | 23-17 |
Home History
| NCAAF | 2021/10/30 19:30 | Florida State v Clemson | W | 20-30 |
| NCAAF | 2021/10/23 19:30 | Clemson v Pittsburgh | L | 17-27 |
| NCAAF | 2021/10/15 23:00 | Clemson v Syracuse | W | 17-14 |
| NCAAF | 2021/10/02 23:30 | Boston College v Clemson | W | 13-19 |
| NCAAF | 2021/09/25 19:30 | Clemson v NC State | L | 21-27 |
| NCAAF | 2021/09/18 19:30 | Georgia Tech v Clemson | W | 8-14 |
| NCAAF | 2021/09/11 21:00 | South Carolina State v Clemson | W | 3-49 |
| NCAAF | 2021/09/04 23:30 | Georgia v Clemson | L | 10-3 |
Away History
| NCAAF | 2021/10/30 23:30 | Louisville v NC State | L | 13-28 |
| NCAAF | 2021/10/23 20:00 | Boston College v Louisville | W | 14-28 |
| NCAAF | 2021/10/09 19:00 | Virginia v Louisville | L | 34-33 |
| NCAAF | 2021/10/02 16:30 | Louisville v Wake Forest | L | 34-37 |
| NCAAF | 2021/09/25 19:30 | Louisville v Florida State | W | 31-23 |
| NCAAF | 2021/09/17 23:30 | Central Florida v Louisville | W | 35-42 |
| NCAAF | 2021/09/11 23:00 | Eastern Kentucky v Louisville | W | 3-30 |
| NCAAF | 2021/09/07 00:00 | Louisville v Mississippi | L | 24-43 |