[52] Clemson 30-24 Louisville [81] 2021-11-06 23:30
Stadium: L&N Federal Credit Union Stadium Round: 1
Home Manager: Scott Satterfield Away Manager: Dabo Swinney
Head to Head
| NCAAF | 2019/10/19 16:00 | Clemson v Louisville | W | 45-10 |
| NCAAF | 2018/11/03 16:00 | Louisville v Clemson | W | 16-77 |
| NCAAF | 2017/09/17 00:00 | Clemson v Louisville | W | 47-21 |
| NCAAF | 2016/10/02 00:00 | Louisville v Clemson | W | 36-42 |
| NCAAF | 2015/09/17 23:30 | Louisville v Clemson | W | 17-20 |
| NCAAF | 2014/10/11 19:30 | Clemson v Louisville | W | 23-17 |