Stadium: Ellis T. Johnson Arena
Home Manager: Cayla Petree Away Manager: Becky Burke
| WNCAAB | 2021/12/15 22:00 | Morehead State Women v Eastern Kentucky Women | L | 43-66 |
| WNCAAB | 2021/12/11 19:00 | Morehead State Women v Evansville Women | L | 49-79 |
| WNCAAB | 2021/12/01 01:00 | Morehead State Women v Baylor Women | L | 28-73 |
| WNCAAB | 2021/11/27 19:00 | Morehead State Women v Bellarmine Women | L | 61-68 |
| WNCAAB | 2021/11/24 21:00 | Morehead State Women v Robert Morris Women | L | 45-69 |
| WNCAAB | 2021/11/21 23:00 | Morehead State Women v Midway Women | W | 72-53 |
| WNCAAB | 2021/11/19 23:00 | Morehead State Women v Marshall Women | L | 58-65 |
| WNCAAB | 2021/11/09 23:00 | Morehead State Women v Michigan State Women | L | 31-93 |
| WNCAAB | 2021/12/16 23:00 | USC Upstate Women v Bob Jones Bruins Women | W | 86-36 |
| WNCAAB | 2021/12/13 23:00 | Jacksonville Women v USC Upstate Women | W | 53-70 |
| WNCAAB | 2021/12/04 19:00 | UNC Greensboro Women v USC Upstate Women | W | 46-57 |
| WNCAAB | 2021/12/02 00:30 | USC Upstate Women v Western Carolina Women | W | 58-51 |
| WNCAAB | 2021/11/28 19:00 | USC Upstate Women v Mars Hill Women | W | 102-40 |
| WNCAAB | 2021/11/22 23:00 | USC Upstate Women v Florida Women | L | 54-76 |
| WNCAAB | 2021/11/19 23:00 | USC Upstate Women v Columbia International Women | W | 81-40 |
| WNCAAB | 2021/11/17 00:00 | South Carolina State Women v USC Upstate Women | W | 51-70 |