Clemson 61-70 Louisville 2022-02-19 20:00
Stadium: KFC Yum! Center
Home Manager: Mike Pegues Away Manager: Brad Brownell
Head to Head
| NCAAB | 2021/01/28 02:00 | Louisville v Clemson | W | 50-54 |
| NCAAB | 2020/02/15 21:00 | Louisville v Clemson | W | 62-77 |
| NCAAB | 2020/01/25 19:00 | Clemson v Louisville | L | 62-80 |
| NCAAB | 2019/02/16 17:00 | Clemson v Louisville | L | 55-56 |
| NCAAB | 2018/01/06 17:00 | Louisville v Clemson | W | 69-74 |
| NCAAB | 2017/01/20 02:00 | Clemson v Louisville | L | 60-92 |
| NCAAB | 2016/01/10 17:00 | Clemson v Louisville | W | 66-62 |
| NCAAB | 2015/01/08 02:00 | Louisville v Clemson | L | 58-52 |
Home History
| NCAAB | 2022/02/16 00:00 | Clemson v Florida State | L | 80-81 |
| NCAAB | 2022/02/13 00:00 | Notre Dame v Clemson | L | 76-61 |
| NCAAB | 2022/02/11 01:00 | Duke v Clemson | L | 82-64 |
| NCAAB | 2022/02/08 23:00 | North Carolina v Clemson | L | 79-77 |
| NCAAB | 2022/02/05 19:00 | Clemson v Georgia Tech | L | 64-69 |
| NCAAB | 2022/02/03 00:00 | Florida State v Clemson | W | 69-75 |
| NCAAB | 2022/01/26 00:00 | Clemson v Duke | L | 69-71 |
| NCAAB | 2022/01/22 23:00 | Pittsburgh v Clemson | W | 48-75 |
Away History
| NCAAB | 2022/02/17 00:00 | Miami Florida v Louisville | L | 70-63 |
| NCAAB | 2022/02/10 00:00 | Louisville v Notre Dame | L | 57-63 |
| NCAAB | 2022/02/05 19:00 | Louisville v Syracuse | L | 69-92 |
| NCAAB | 2022/02/02 01:00 | North Carolina v Louisville | L | 90-83 |
| NCAAB | 2022/01/29 17:00 | Duke v Louisville | L | 74-65 |
| NCAAB | 2022/01/25 00:00 | Louisville v Virginia | L | 52-64 |
| NCAAB | 2022/01/22 21:00 | Notre Dame v Louisville | L | 82-70 |
| NCAAB | 2022/01/20 00:00 | Boston College v Louisville | W | 54-67 |