Clemson 61-70 Louisville 2022-02-19 20:00
Stadium: KFC Yum! Center
Home Manager: Mike Pegues Away Manager: Brad Brownell
Head to Head
| NCAAB | 2021/01/28 02:00 | Louisville v Clemson | W | 50-54 |
| NCAAB | 2020/02/15 21:00 | Louisville v Clemson | W | 62-77 |
| NCAAB | 2020/01/25 19:00 | Clemson v Louisville | L | 62-80 |
| NCAAB | 2019/02/16 17:00 | Clemson v Louisville | L | 55-56 |
| NCAAB | 2018/01/06 17:00 | Louisville v Clemson | W | 69-74 |
| NCAAB | 2017/01/20 02:00 | Clemson v Louisville | L | 60-92 |
| NCAAB | 2016/01/10 17:00 | Clemson v Louisville | W | 66-62 |
| NCAAB | 2015/01/08 02:00 | Louisville v Clemson | L | 58-52 |
| NIT | 2006/03/20 12:00 | Louisville v Clemson | L | 74-68 |