Southern Illinois 22-10 South Dakota 2021-11-27 23:00
Stadium: DakotaDome Round: 1
Home Manager: Bob Nielson Away Manager: Nick Hill
Head to Head
| NCAAF | 2019/10/26 21:00 | SO Illinois v South Dakota | W | 48-28 |
| NCAAF | 2018/09/29 23:00 | South Dakota v SO Illinois | L | 31-24 |
| NCAAF | 2017/10/28 20:00 | South Dakota v SO Illinois | L | 42-0 |
Home History
| NCAAF | 2021/11/20 18:00 | Youngstown State v SO Illinois | L | 35-18 |
| NCAAF | 2021/11/13 18:00 | SO Illinois v Indiana State | W | 47-21 |
| NCAAF | 2021/11/06 17:00 | Missouri St v SO Illinois | L | 38-28 |
| NCAAF | 2021/10/30 21:00 | SO Illinois v Northern Iowa | L | 16-23 |
| NCAAF | 2021/10/16 19:00 | North Dakota v SO Illinois | W | 28-31 |
| NCAAF | 2021/10/09 19:00 | SO Illinois v South Dakota State | W | 42-41 |
| NCAAF | 2021/10/02 20:00 | SO Illinois v Western Illinois | W | 31-30 |
| NCAAF | 2021/09/25 19:00 | Illinois State v SO Illinois | W | 17-35 |
Away History
| NCAAF | 2021/11/20 20:30 | South Dakota v North Dakota State | L | 24-52 |
| NCAAF | 2021/11/13 19:00 | South Dakota State v South Dakota | W | 20-23 |
| NCAAF | 2021/11/06 17:00 | South Dakota v Western Illinois | W | 42-21 |
| NCAAF | 2021/10/23 18:00 | Illinois State v South Dakota | L | 20-14 |
| NCAAF | 2021/10/16 21:00 | South Dakota v Northern Iowa | W | 34-21 |
| NCAAF | 2021/10/09 19:00 | North Dakota v South Dakota | W | 13-20 |
| NCAAF | 2021/10/02 19:00 | Indiana State v South Dakota | W | 10-38 |
| NCAAF | 2021/09/26 00:00 | South Dakota v Missouri St | L | 23-31 |