Stadium: Dana J. Dykhouse Stadium Round: 1
Home Manager: John Stiegelmeier Away Manager: Dan Hawkins
| NCAAF | 2021/11/20 21:00 | CS Sacramento v UC Davis | L | 27-7 |
| NCAAF | 2021/11/14 01:00 | East Washington v UC Davis | L | 38-20 |
| NCAAF | 2021/11/06 20:00 | UC Davis v Northern Arizona | W | 40-24 |
| NCAAF | 2021/10/24 00:00 | UC Davis v Cal Poly | W | 24-13 |
| NCAAF | 2021/10/17 00:00 | Northern Colorado v UC Davis | W | 3-32 |
| NCAAF | 2021/10/09 19:00 | UC Davis v Idaho State | L | 17-27 |
| NCAAF | 2021/10/03 02:00 | Idaho v UC Davis | W | 20-27 |
| NCAAF | 2021/09/26 00:00 | UC Davis v Weber State | W | 17-14 |
| NCAAF | 2021/11/20 20:00 | North Dakota v South Dakota State | W | 21-24 |
| NCAAF | 2021/11/13 19:00 | South Dakota State v South Dakota | L | 20-23 |
| NCAAF | 2021/11/06 19:00 | North Dakota State v South Dakota State | W | 19-27 |
| NCAAF | 2021/10/30 18:00 | South Dakota State v Youngstown State | W | 47-16 |
| NCAAF | 2021/10/23 19:00 | Northern Iowa v South Dakota State | L | 26-17 |
| NCAAF | 2021/10/16 17:00 | South Dakota State v Western Illinois | W | 41-17 |
| NCAAF | 2021/10/09 19:00 | SO Illinois v South Dakota State | L | 42-41 |
| NCAAF | 2021/10/02 23:00 | Utah Tech v South Dakota State | W | 7-55 |