[13] Leyton Orient 0-1 Tranmere [9] 2022-05-07 14:00
Stadium: Matchroom Stadium Round: 46
Referee: Sebastian Stockbridge Home Manager: Richie Wellens Away Manager: Micky Mellon
Head to Head
| England League 2 | 2021/12/18 15:00 | Tranmere v Leyton Orient | L | 1-0 |
| England FA Cup | 2021/12/04 15:00 | Leyton Orient v Tranmere | W | 4-0 |
| England League 2 | 2021/02/27 15:00 | Leyton Orient v Tranmere | L | 1-3 |
| England League 2 | 2020/10/20 18:00 | Tranmere v Leyton Orient | W | 0-1 |
| England National League | 2018/02/10 15:00 | Leyton Orient v Tranmere | D | 1-1 |
| England National League | 2017/10/04 18:45 | Tranmere v Leyton Orient | L | 2-1 |
Home History
| England League 2 | 2022/04/30 14:00 | Crawley Town v Leyton Orient | W | 0-2 |
| England League 2 | 2022/04/23 14:00 | Leyton Orient v Northampton | L | 2-4 |
| England League 2 | 2022/04/18 14:00 | Swindon v Leyton Orient | W | 1-2 |
| England League 2 | 2022/04/15 14:00 | Leyton Orient v Scunthorpe | W | 3-0 |
| England League 2 | 2022/04/09 14:00 | Sutton Utd v Leyton Orient | L | 1-0 |
| England League 2 | 2022/04/02 14:00 | Walsall v Leyton Orient | W | 0-2 |
| England League 2 | 2022/03/29 18:45 | Oldham v Leyton Orient | L | 2-0 |
| England League 2 | 2022/03/26 15:00 | Leyton Orient v Barrow | W | 2-0 |
Away History
| England League 2 | 2022/04/30 14:00 | Tranmere v Oldham | W | 2-0 |
| England League 2 | 2022/04/23 14:00 | Stevenage v Tranmere | L | 2-0 |
| England League 2 | 2022/04/18 14:00 | Tranmere v Exeter | W | 2-0 |
| England League 2 | 2022/04/15 14:00 | Bradford v Tranmere | D | 1-1 |
| England League 2 | 2022/04/09 14:00 | Tranmere v Bristol Rovers | D | 1-1 |
| England League 2 | 2022/04/02 14:00 | Tranmere v Carlisle | D | 2-2 |
| England League 2 | 2022/03/26 15:00 | Colchester v Tranmere | L | 1-0 |
| England League 2 | 2022/03/19 15:00 | Sutton Utd v Tranmere | D | 1-1 |