[13] Leyton Orient 0-1 Tranmere [9] 2022-05-07 14:00
Stadium: Matchroom Stadium Round: 46
Referee: Sebastian Stockbridge Home Manager: Richie Wellens Away Manager: Micky Mellon
Head to Head
| England League 2 | 2021/12/18 15:00 | Tranmere v Leyton Orient | L | 1-0 |
| England FA Cup | 2021/12/04 15:00 | Leyton Orient v Tranmere | W | 4-0 |
| England League 2 | 2021/02/27 15:00 | Leyton Orient v Tranmere | L | 1-3 |
| England League 2 | 2020/10/20 18:00 | Tranmere v Leyton Orient | W | 0-1 |
| England National League | 2018/02/10 15:00 | Leyton Orient v Tranmere | D | 1-1 |
| England National League | 2017/10/04 18:45 | Tranmere v Leyton Orient | L | 2-1 |