South Dakota State 35-21 Villanova 2021-12-11 19:00
Stadium: Villanova Stadium Round: 1
Home Manager: Mark Ferrante Away Manager: John Stiegelmeier
Home History
| NCAAF | 2021/12/05 02:00 | South Dakota State v CS Sacramento | W | 24-19 |
| NCAAF | 2021/11/27 20:00 | UC Davis v South Dakota State | W | 24-56 |
| NCAAF | 2021/11/20 20:00 | North Dakota v South Dakota State | W | 21-24 |
| NCAAF | 2021/11/13 19:00 | South Dakota State v South Dakota | L | 20-23 |
| NCAAF | 2021/11/06 19:00 | North Dakota State v South Dakota State | W | 19-27 |
| NCAAF | 2021/10/30 18:00 | South Dakota State v Youngstown State | W | 47-16 |
| NCAAF | 2021/10/23 19:00 | Northern Iowa v South Dakota State | L | 26-17 |
| NCAAF | 2021/10/16 17:00 | South Dakota State v Western Illinois | W | 41-17 |
Away History
| NCAAF | 2021/12/04 00:00 | Holy Cross v Villanova | W | 16-21 |
| NCAAF | 2021/11/20 18:00 | Villanova v Delaware | W | 21-13 |
| NCAAF | 2021/11/13 18:00 | Stony Brook v Villanova | W | 14-33 |
| NCAAF | 2021/11/06 18:00 | Villanova v Elon | W | 35-0 |
| NCAAF | 2021/10/30 17:00 | William & Mary v Villanova | L | 31-18 |
| NCAAF | 2021/10/23 19:30 | Rhode Island v Villanova | W | 0-44 |
| NCAAF | 2021/10/16 19:30 | Villanova v Albany | W | 17-10 |
| NCAAF | 2021/10/09 18:00 | Villanova v James Madison | W | 28-27 |