[15] Santos Laguna 3-1 Pachuca [1] 2022-04-04 00:00
Stadium: Estadio TSM Corona Round: 12
Referee: Adonai Escobedo Gonzalez Home Manager: Eduardo Fentanes Away Manager: Guillermo Almada
Head to Head
| Mexico Liga MX | 2021/10/17 00:00 | Pachuca v Santos Laguna | D | 1-1 |
| Mexico Liga MX | 2021/04/27 02:00 | Pachuca v Santos Laguna | L | 1-0 |
| Mexico Liga MX | 2020/11/22 01:00 | Santos Laguna v Pachuca | L | 0-3 |
| Mexico Liga MX | 2020/10/19 00:06 | Santos Laguna v Pachuca | D | 1-1 |
| Mexico Liga MX | 2020/03/08 01:00 | Pachuca v Santos Laguna | L | 1-0 |
| Mexico Liga MX | 2019/09/15 23:45 | Santos Laguna v Pachuca | D | 2-2 |
| Mexico Liga MX | 2019/04/07 23:06 | Santos Laguna v Pachuca | D | 0-0 |
| Mexico Liga MX | 2018/10/21 00:00 | Pachuca v Santos Laguna | D | 1-1 |
Home History
| Mexico Liga MX | 2022/03/19 03:00 | Puebla v Santos Laguna | D | 2-2 |
| Mexico Liga MX | 2022/03/14 01:00 | Santos Laguna v Tijuana | W | 4-0 |
| Mexico Liga MX | 2022/03/06 03:00 | Chivas Guadalajara v Santos Laguna | L | 1-0 |
| Mexico Liga MX | 2022/03/03 03:00 | Santos Laguna v Unam Pumas | W | 3-2 |
| Mexico Liga MX | 2022/02/28 01:00 | Cruz Azul v Santos Laguna | W | 1-2 |
| CONCACAF Champions Cup | 2022/02/24 01:15 | CF Montreal v Santos Laguna | L | 3-0 |
| Mexico Liga MX | 2022/02/19 03:00 | Juarez FC v Santos Laguna | D | 0-0 |
| CONCACAF Champions Cup | 2022/02/16 03:00 | Santos Laguna v CF Montreal | W | 1-0 |
Away History
| Mexico Liga MX | 2022/03/20 03:00 | Pachuca v Cruz Azul | W | 1-0 |
| Mexico Liga MX | 2022/03/13 18:00 | Toluca v Pachuca | W | 0-3 |
| Mexico Liga MX | 2022/03/03 01:00 | Atlas v Pachuca | W | 0-1 |
| Mexico Liga MX | 2022/02/25 01:00 | Pachuca v Mazatlan FC | W | 3-1 |
| Mexico Liga MX | 2022/02/20 22:00 | Club America v Pachuca | W | 1-3 |
| Mexico Liga MX | 2022/02/15 03:00 | Pachuca v Queretaro | D | 2-2 |
| Mexico Liga MX | 2022/02/05 23:00 | Necaxa v Pachuca | W | 1-3 |
| Mexico Liga MX | 2022/01/23 01:00 | Leon v Pachuca | L | 2-1 |