[17] Mazatlan FC 1-0 Santos Laguna [14] 2022-04-20 02:00
Stadium: Estadio de Mazatlan Round: 15
Referee: Fernando Hernandez Gomez Home Manager: Gabriel Caballero Away Manager: Eduardo Fentanes
Head to Head
| Club Friendly List | 2022/01/29 02:00 | Mazatlan FC v Santos Laguna | W | 2-1 |
| Mexico Liga MX | 2021/10/03 00:06 | Santos Laguna v Mazatlan FC | L | 1-0 |
| Mexico Liga MX | 2021/01/23 03:30 | Mazatlan FC v Santos Laguna | D | 0-0 |
| Mexico Liga MX | 2020/11/09 01:06 | Santos Laguna v Mazatlan FC | L | 4-0 |
| Mexico Liga MX | 2016/07/31 23:00 | Santos Laguna v Mazatlan FC | W | 2-4 |
| Mexico Liga MX | 2016/05/01 01:30 | Mazatlan FC v Santos Laguna | W | 3-2 |
| Mexico Liga MX | 2015/11/07 03:30 | Santos Laguna v Mazatlan FC | W | 2-3 |
| Mexico Liga MX | 2015/04/04 01:30 | Mazatlan FC v Santos Laguna | L | 0-1 |
Home History
| Mexico Liga MX | 2022/04/15 02:00 | Atlas v Mazatlan FC | W | 1-2 |
| Mexico Liga MX | 2022/04/09 02:00 | Mazatlan FC v Cruz Azul | D | 1-1 |
| Mexico Liga MX | 2022/04/02 02:00 | Atletico San Luis v Mazatlan FC | L | 1-0 |
| Mexico Liga MX | 2022/03/26 23:00 | Unam Pumas v Mazatlan FC | D | 1-1 |
| Mexico Liga MX | 2022/03/21 03:00 | Mazatlan FC v Leon | L | 1-2 |
| Mexico Liga MX | 2022/03/12 03:06 | Monterrey v Mazatlan FC | L | 2-1 |
| Mexico Liga MX | 2022/03/02 03:00 | Mazatlan FC v Necaxa | D | 0-0 |
| Mexico Liga MX | 2022/02/25 01:00 | Pachuca v Mazatlan FC | L | 3-1 |
Away History
| Mexico Liga MX | 2022/04/17 00:00 | Santos Laguna v Queretaro | D | 1-1 |
| Mexico Liga MX | 2022/04/10 00:06 | Monterrey v Santos Laguna | L | 1-0 |
| Mexico Liga MX | 2022/04/04 00:00 | Santos Laguna v Pachuca | W | 3-1 |
| Mexico Liga MX | 2022/03/19 03:00 | Puebla v Santos Laguna | D | 2-2 |
| Mexico Liga MX | 2022/03/14 01:00 | Santos Laguna v Tijuana | W | 4-0 |
| Mexico Liga MX | 2022/03/06 03:00 | Chivas Guadalajara v Santos Laguna | L | 1-0 |
| Mexico Liga MX | 2022/03/03 03:00 | Santos Laguna v Unam Pumas | W | 3-2 |
| Mexico Liga MX | 2022/02/28 01:00 | Cruz Azul v Santos Laguna | W | 1-2 |