[11] St Lucia 0-1 Hamrun Spartans [5] 2022-03-06 13:00
Stadium: Luxol Sports Ground Round: 21
Home Manager: Oliver Spiteri Away Manager: Mark Buttigieg
Head to Head
| Malta Premier League | 2021/11/28 15:00 | Hamrun Spartans v Santa Lucia FC | L | 3-0 |
| Europe Friendlies | 2021/07/16 18:00 | Hamrun Spartans v Santa Lucia FC | D | 0-0 |
| Malta Premier League | 2021/01/24 17:00 | Hamrun Spartans v Santa Lucia FC | D | 2-2 |
| Malta Premier League | 2020/09/27 15:00 | Santa Lucia FC v Hamrun Spartans | L | 1-4 |
| Malta Premier League | 2019/11/01 19:15 | Hamrun Spartans v Santa Lucia FC | D | 1-1 |
Home History
| Malta Premier League | 2022/02/27 13:00 | Birkirkara v Santa Lucia FC | W | 2-3 |
| Malta Premier League | 2022/02/20 13:00 | Santa Lucia FC v Valletta | W | 2-1 |
| Malta Premier League | 2022/02/13 15:00 | Sliema Wanderers v Santa Lucia FC | D | 1-1 |
| Malta FA Trophy | 2022/02/10 18:00 | Santa Lucia FC v Sirens | W | 4-1 |
| Malta Premier League | 2022/02/05 13:00 | Mosta FC v Santa Lucia FC | L | 1-0 |
| Malta Premier League | 2022/01/29 13:00 | Santa Lucia FC v Hibernians | D | 0-0 |
| Malta Premier League | 2022/01/23 15:00 | Sirens v Santa Lucia FC | L | 2-1 |
| Malta Premier League | 2022/01/19 16:00 | Santa Lucia FC v Gudja United | L | 0-3 |
Away History
| Malta Premier League | 2022/02/26 15:00 | Hamrun Spartans v Hibernians | D | 0-0 |
| Malta Premier League | 2022/02/19 17:00 | Sirens v Hamrun Spartans | D | 1-1 |
| Malta Premier League | 2022/02/13 13:00 | Hamrun Spartans v Gudja United | L | 0-1 |
| Malta FA Trophy | 2022/02/10 10:00 | Hamrun Spartans v Naxxar Lions | W | 1-0 |
| Malta Premier League | 2022/02/05 15:00 | Gzira United v Hamrun Spartans | L | 4-1 |
| Malta Premier League | 2022/01/30 13:00 | Hamrun Spartans v Floriana | D | 2-2 |
| Malta Premier League | 2022/01/26 18:00 | Hamrun Spartans v Birkirkara | D | 0-0 |
| Malta Premier League | 2022/01/22 13:00 | Balzan FC v Hamrun Spartans | D | 2-2 |