[11] St Lucia 0-1 Hamrun Spartans [5] 2022-03-06 13:00
Stadium: Luxol Sports Ground Round: 21
Home Manager: Oliver Spiteri Away Manager: Mark Buttigieg
Head to Head
| Malta Premier League | 2021/11/28 15:00 | Hamrun Spartans v Santa Lucia FC | L | 3-0 |
| Europe Friendlies | 2021/07/16 18:00 | Hamrun Spartans v Santa Lucia FC | D | 0-0 |
| Malta Premier League | 2021/01/24 17:00 | Hamrun Spartans v Santa Lucia FC | D | 2-2 |
| Malta Premier League | 2020/09/27 15:00 | Santa Lucia FC v Hamrun Spartans | L | 1-4 |
| Malta Premier League | 2019/11/01 19:15 | Hamrun Spartans v Santa Lucia FC | D | 1-1 |