[7] CD Real Santander 2-3 Barranquilla FC [15] 2022-02-13 20:00
Stadium: Estadio Americo Montanini Round: 4
Head to Head
| Colombia Cup | 2022/02/09 19:10 | Real San Andres v Barranquilla FC | W | 3-0 |
| Colombia Primera B | 2021/09/11 16:00 | Real San Andres v Barranquilla FC | D | 1-1 |
| Colombia Primera B | 2021/02/06 20:00 | Barranquilla FC v Real San Andres | L | 1-0 |
| Colombia Primera B | 2020/02/23 20:30 | Real San Andres v Barranquilla FC | W | 2-0 |
| Colombia Primera B | 2019/09/01 20:30 | Real San Andres v Barranquilla FC | W | 1-0 |
| Colombia Cup | 2019/04/25 20:30 | Real San Andres v Barranquilla FC | W | 3-1 |
| Colombia Cup | 2019/04/10 20:00 | Barranquilla FC v Real San Andres | L | 1-0 |
| Colombia Primera B | 2019/03/16 20:00 | Barranquilla FC v Real San Andres | L | 2-0 |
Home History
| Colombia Cup | 2022/02/09 19:10 | Real San Andres v Barranquilla FC | W | 3-0 |
| Colombia Primera B | 2022/02/06 20:00 | Fortaleza CEIF v Real San Andres | W | 2-3 |
| Colombia Primera B | 2022/01/30 20:00 | Real San Andres v Tigres FC | D | 0-0 |
| Colombia Primera B | 2022/01/23 20:00 | Valledupar FC v Real San Andres | L | 1-0 |
| Colombia Primera B | 2021/10/24 20:00 | Real San Andres v Fortaleza CEIF | D | 1-1 |
| Colombia Primera B | 2021/10/19 23:00 | Boyaca Chico v Real San Andres | L | 3-1 |
| Colombia Primera B | 2021/10/09 20:00 | Real San Andres v Valledupar FC | D | 1-1 |
| Colombia Primera B | 2021/10/02 20:00 | Orsomarso v Real San Andres | L | 3-1 |
Away History
| Colombia Cup | 2022/02/09 19:10 | Real San Andres v Barranquilla FC | L | 3-0 |
| Colombia Primera B | 2022/02/05 23:10 | Barranquilla FC v Real Cartagena | L | 0-2 |
| Colombia Primera B | 2022/01/30 00:00 | Atletico Huila v Barranquilla FC | D | 0-0 |
| Colombia Primera B | 2021/10/30 21:00 | Barranquilla FC v Tigres FC | W | 2-0 |
| Colombia Primera B | 2021/10/24 20:00 | Llaneros v Barranquilla FC | L | 4-2 |
| Colombia Primera B | 2021/10/19 01:00 | Barranquilla FC v Leones | L | 0-1 |
| Colombia Primera B | 2021/10/11 23:00 | Real Cartagena v Barranquilla FC | L | 3-1 |
| Colombia Primera B | 2021/10/02 22:00 | Barranquilla FC v Boca Juniors De Cali | W | 1-0 |