[7] CD Real Santander 2-3 Barranquilla FC [15] 2022-02-13 20:00
Stadium: Estadio Americo Montanini Round: 4
Head to Head
| Colombia Cup | 2022/02/09 19:10 | Real San Andres v Barranquilla FC | W | 3-0 |
| Colombia Primera B | 2021/09/11 16:00 | Real San Andres v Barranquilla FC | D | 1-1 |
| Colombia Primera B | 2021/02/06 20:00 | Barranquilla FC v Real San Andres | L | 1-0 |
| Colombia Primera B | 2020/02/23 20:30 | Real San Andres v Barranquilla FC | W | 2-0 |
| Colombia Primera B | 2019/09/01 20:30 | Real San Andres v Barranquilla FC | W | 1-0 |
| Colombia Cup | 2019/04/25 20:30 | Real San Andres v Barranquilla FC | W | 3-1 |
| Colombia Cup | 2019/04/10 20:00 | Barranquilla FC v Real San Andres | L | 1-0 |
| Colombia Primera B | 2019/03/16 20:00 | Barranquilla FC v Real San Andres | L | 2-0 |
| Colombia Primera B | 2018/09/02 23:00 | Real San Andres v Barranquilla FC | L | 1-2 |
| Colombia Primera B | 2018/04/07 20:00 | Barranquilla FC v Real San Andres | W | 1-4 |
| Colombia Primera B | 2017/07/02 23:00 | Real San Andres v Barranquilla FC | L | 0-1 |
| Colombia Primera B | 2017/02/11 16:00 | Barranquilla FC v Real San Andres | W | 0-1 |
| Colombia Primera B | 2016/10/12 20:00 | Barranquilla FC v Real San Andres | D | 1-1 |
| Colombia Primera B | 2016/05/21 23:00 | Real San Andres v Barranquilla FC | L | 0-2 |
| Colombia Primera B | 2015/09/20 20:00 | Real San Andres v Barranquilla FC | D | 0-0 |
| Colombia Primera B | 2015/04/25 20:00 | Barranquilla FC v Real San Andres | L | 2-0 |
| Colombia Primera B | 2014/10/19 20:00 | Real San Andres v Barranquilla FC | W | 1-0 |