[8] STL Blues 6-2 BUF Sabres [25] 2022-04-14 23:00
Stadium: KeyBank Center
Home Manager: Don Granato Away Manager: Craig Berube
Head to Head
| NHL | 2022/02/26 01:00 | BUF Sabres v STL Blues | W | 3-5 |
| NHL | 2020/01/10 01:00 | BUF Sabres v STL Blues | W | 1-5 |
| NHL | 2019/12/11 00:30 | STL Blues v BUF Sabres | L | 2-5 |
| NHL | 2019/03/17 21:00 | STL Blues v BUF Sabres | L | 3-4 |
| NHL | 2018/12/28 01:00 | BUF Sabres v STL Blues | W | 1-4 |
| NHL | 2018/02/04 00:00 | STL Blues v BUF Sabres | W | 1-0 |
| NHL | 2017/12/11 00:00 | BUF Sabres v STL Blues | W | 2-3 |
| NHL | 2017/02/18 18:00 | STL Blues v BUF Sabres | L | 2-3 |
Home History
| NHL | 2022/04/12 23:00 | STL Blues v BOS Bruins | W | 4-2 |
| NHL | 2022/04/10 00:00 | NY Islanders v STL Blues | W | 1-6 |
| NHL | 2022/04/09 00:00 | MIN Wild v STL Blues | W | 3-4 |
| NHL | 2022/04/07 00:00 | SEA Kraken v STL Blues | W | 1-4 |
| NHL | 2022/04/05 00:00 | ARZ Coyotes v STL Blues | W | 1-5 |
| NHL | 2022/04/03 02:00 | STL Blues v CAL Flames | W | 6-4 |
| NHL | 2022/04/02 01:00 | STL Blues v EDM Oilers | L | 5-6 |
| NHL | 2022/03/31 02:00 | STL Blues v VAN Canucks | W | 4-3 |
Away History
| NHL | 2022/04/12 23:00 | BUF Sabres v TOR Maple Leafs | W | 5-2 |
| NHL | 2022/04/10 21:00 | BUF Sabres v TB Lightning | L | 0-5 |
| NHL | 2022/04/08 23:00 | BUF Sabres v FLA Panthers | L | 3-4 |
| NHL | 2022/04/07 23:30 | BUF Sabres v CAR Hurricanes | L | 3-5 |
| NHL | 2022/04/05 23:00 | CAR Hurricanes v BUF Sabres | W | 2-4 |
| NHL | 2022/04/03 17:00 | FLA Panthers v BUF Sabres | L | 5-3 |
| NHL | 2022/04/01 23:00 | NAS Predators v BUF Sabres | W | 3-4 |
| NHL | 2022/03/30 23:00 | WIN Jets v BUF Sabres | L | 3-2 |