[8] STL Blues 6-2 BUF Sabres [25] 2022-04-14 23:00
Stadium: KeyBank Center
Home Manager: Don Granato Away Manager: Craig Berube
Head to Head
| NHL | 2022/02/26 01:00 | BUF Sabres v STL Blues | W | 3-5 |
| NHL | 2020/01/10 01:00 | BUF Sabres v STL Blues | W | 1-5 |
| NHL | 2019/12/11 00:30 | STL Blues v BUF Sabres | L | 2-5 |
| NHL | 2019/03/17 21:00 | STL Blues v BUF Sabres | L | 3-4 |
| NHL | 2018/12/28 01:00 | BUF Sabres v STL Blues | W | 1-4 |
| NHL | 2018/02/04 00:00 | STL Blues v BUF Sabres | W | 1-0 |
| NHL | 2017/12/11 00:00 | BUF Sabres v STL Blues | W | 2-3 |
| NHL | 2017/02/18 18:00 | STL Blues v BUF Sabres | L | 2-3 |
| NHL | 2016/11/16 01:00 | BUF Sabres v STL Blues | W | 1-4 |