[5] Nacional Potosi 1-0 Real Santa Cruz [6] 2022-02-18 21:15
Stadium: Estadio Victor Agustín Ugarte Round: 3
Head to Head
| Bolivia Apertura | 2021/12/01 19:00 | Real Santa Cruz v Nacional Potosi | D | 1-1 |
| Bolivia Apertura | 2021/08/03 22:15 | Nacional Potosi v Real Santa Cruz | D | 2-2 |
| Bolivia Apertura | 2020/12/27 19:00 | Nacional Potosi v Real Santa Cruz | W | 1-0 |
| Bolivia Apertura | 2020/03/06 19:00 | Real Santa Cruz v Nacional Potosi | L | 2-1 |
Home History
| Bolivia Apertura | 2022/02/12 23:30 | Universitario de Sucre v Nacional Potosi | L | 4-3 |
| Bolivia Apertura | 2022/02/05 21:15 | Nacional Potosi v Atletico Palmaflor Vinto | D | 1-1 |
| Bolivia Apertura | 2021/12/10 19:00 | Nacional Potosi v Oriente Petrolero | W | 1-0 |
| Bolivia Apertura | 2021/12/05 19:00 | Independiente Petrolero v Nacional Potosi | L | 2-0 |
| Bolivia Apertura | 2021/12/01 19:00 | Real Santa Cruz v Nacional Potosi | D | 1-1 |
| Bolivia Clausura | 2021/11/26 19:00 | Nacional Potosi v San Jose | W | 7-1 |
| Bolivia Apertura | 2021/11/23 00:00 | Real Tomayapo v Nacional Potosi | L | 3-0 |
| Bolivia Apertura | 2021/10/31 21:15 | Nacional Potosi v Club Aurora | D | 0-0 |
Away History
| Bolivia Apertura | 2022/02/13 19:00 | Real Santa Cruz v Guabira | D | 2-2 |
| Bolivia Apertura | 2022/02/06 16:00 | Real Santa Cruz v Universitario de Sucre | L | 0-1 |
| America Friendlies | 2022/01/27 21:21 | Royal Pari FC v Real Santa Cruz | D | 1-1 |
| America Friendlies | 2022/01/23 21:00 | Royal Pari FC v Real Santa Cruz | L | 3-1 |
| Bolivia Apertura | 2021/12/12 19:00 | Real Santa Cruz v The Strongest | W | 1-0 |
| Bolivia Apertura | 2021/12/05 00:30 | Oriente Petrolero v Real Santa Cruz | L | 2-0 |
| Bolivia Apertura | 2021/12/01 19:00 | Real Santa Cruz v Nacional Potosi | D | 1-1 |
| Bolivia Apertura | 2021/11/27 23:30 | Independiente Petrolero v Real Santa Cruz | L | 2-1 |