[5] Nacional Potosi 1-0 Real Santa Cruz [6] 2022-02-18 21:15
Stadium: Estadio Victor Agustín Ugarte Round: 3
Head to Head
| Bolivia Apertura | 2021/12/01 19:00 | Real Santa Cruz v Nacional Potosi | D | 1-1 |
| Bolivia Apertura | 2021/08/03 22:15 | Nacional Potosi v Real Santa Cruz | D | 2-2 |
| Bolivia Apertura | 2020/12/27 19:00 | Nacional Potosi v Real Santa Cruz | W | 1-0 |
| Bolivia Apertura | 2020/03/06 19:00 | Real Santa Cruz v Nacional Potosi | L | 2-1 |