[9] Southampton 1-2 Newcastle [14] 2022-03-10 19:30
Stadium: St. Mary's Stadium Round: 21
Referee: Kevin Friend Home Manager: Ralph Hasenhuttl Away Manager: Eddie Howe
Head to Head
| England Premier League | 2021/08/28 14:00 | Newcastle v Southampton | D | 2-2 |
| England Premier League | 2021/02/06 15:00 | Newcastle v Southampton | L | 3-2 |
| England Premier League | 2020/11/06 20:00 | Southampton v Newcastle | W | 2-0 |
| England Premier League | 2020/03/07 15:00 | Southampton v Newcastle | L | 0-1 |
| England Premier League | 2019/12/08 14:00 | Newcastle v Southampton | L | 2-1 |
| England Premier League | 2019/04/20 16:30 | Newcastle v Southampton | L | 3-1 |
| England Premier League | 2018/10/27 14:00 | Southampton v Newcastle | D | 0-0 |
| England Premier League | 2018/03/10 15:00 | Newcastle v Southampton | L | 3-0 |
Home History
| England Premier League | 2022/03/05 15:00 | Aston Villa v Southampton | L | 4-0 |
| England FA Cup | 2022/03/02 19:30 | Southampton v West Ham | W | 3-1 |
| England Premier League | 2022/02/25 20:00 | Southampton v Norwich | W | 2-0 |
| England Premier League | 2022/02/19 15:00 | Southampton v Everton | W | 2-0 |
| England Premier League | 2022/02/12 12:30 | Man Utd v Southampton | D | 1-1 |
| England Premier League | 2022/02/09 19:45 | Tottenham v Southampton | W | 2-3 |
| England FA Cup | 2022/02/05 15:00 | Southampton v Coventry | D | 1-1 |
| England Premier League | 2022/01/22 17:30 | Southampton v Man City | D | 1-1 |
Away History
| England Premier League | 2022/03/05 15:00 | Newcastle v Brighton | W | 2-1 |
| England Premier League | 2022/02/26 15:00 | Brentford v Newcastle | W | 0-2 |
| England Premier League | 2022/02/19 12:30 | West Ham v Newcastle | D | 1-1 |
| England Premier League | 2022/02/13 14:00 | Newcastle v Aston Villa | W | 1-0 |
| England Premier League | 2022/02/08 19:45 | Newcastle v Everton | W | 3-1 |
| England Premier League | 2022/01/22 15:00 | Leeds v Newcastle | W | 0-1 |
| England Premier League | 2022/01/15 15:00 | Newcastle v Watford | D | 1-1 |
| England FA Cup | 2022/01/08 15:00 | Newcastle v Cambridge Utd | L | 0-1 |