[8] Guabira 1-0 Real Santa Cruz [7] 2022-04-21 22:15
Stadium: Estadio Ramon Tahuichi Aguilera Round: 10
Head to Head
| Bolivia Apertura | 2022/02/13 19:00 | Real Santa Cruz v Guabira | D | 2-2 |
| Bolivia Apertura | 2021/09/27 19:00 | Real Santa Cruz v Guabira | L | 3-0 |
| Bolivia Apertura | 2021/05/01 23:30 | Guabira v Real Santa Cruz | W | 1-0 |
| Bolivia Apertura | 2020/12/29 19:00 | Real Santa Cruz v Guabira | D | 4-4 |
| Bolivia Apertura | 2020/03/15 21:15 | Guabira v Real Santa Cruz | W | 1-0 |
Home History
| Bolivia Apertura | 2022/04/17 21:15 | Guabira v Club Aurora | W | 3-2 |
| Bolivia Apertura | 2022/04/10 19:00 | Universitario de Sucre v Guabira | L | 2-0 |
| Bolivia Apertura | 2022/04/03 19:00 | Guabira v The Strongest | L | 1-3 |
| America Friendlies | 2022/03/27 19:00 | Guabira v Independiente Petrolero | W | 2-1 |
| Bolivia Apertura | 2022/03/21 00:30 | Guabira v Royal Pari FC | L | 0-3 |
| Copa Sudamericana | 2022/03/18 00:30 | Guabira v Jorge Wilstermann | W | 3-0 |
| Copa Sudamericana | 2022/03/11 00:30 | Jorge Wilstermann v Guabira | L | 4-0 |
| Bolivia Apertura | 2022/03/05 19:00 | Atletico Palmaflor Vinto v Guabira | L | 1-0 |
Away History
| Bolivia Apertura | 2022/04/16 00:00 | Universitario de Sucre v Real Santa Cruz | W | 2-3 |
| Bolivia Apertura | 2022/04/09 19:00 | Atletico Palmaflor Vinto v Real Santa Cruz | L | 2-1 |
| Bolivia Apertura | 2022/04/02 19:00 | Real Santa Cruz v Oriente Petrolero | W | 2-1 |
| Bolivia Apertura | 2022/03/12 19:00 | Real Santa Cruz v Always Ready | L | 0-1 |
| Bolivia Apertura | 2022/03/06 19:00 | Real Santa Cruz v Club Aurora | D | 2-2 |
| Bolivia Apertura | 2022/02/26 19:00 | Real Santa Cruz v The Strongest | L | 1-2 |
| Bolivia Apertura | 2022/02/18 21:15 | Nacional Potosi v Real Santa Cruz | L | 1-0 |
| Bolivia Apertura | 2022/02/13 19:00 | Real Santa Cruz v Guabira | D | 2-2 |