[30] Frances Tiafoe 4-6,6-2,3-6 John Isner [27] 2022-04-08 23:00
Stadium: Stadium Court Round: 27 Ground: Clay
Head to Head
| ATP Cincinnati | 2017/08/17 21:45 | John Isner v Frances Tiafoe | 7-6,7-5 |
| US Open | 2016/08/29 17:30 | John Isner v Frances Tiafoe | 3-6,4-6,7-6,6-2,7-6 |
Home History
| ATP Houston | 2022/04/07 21:30 | Frances Tiafoe v Pablo Cuevas | 5-7,7-5,7-6 |
| ATP Houston | 2022/04/06 02:00 | Frances Tiafoe v Marcos Giron | 6-4,6-4 |
| ATP Miami | 2022/03/29 18:55 | Francisco Cerundolo v Frances Tiafoe | 6-7,7-6,6-2 |
| ATP Miami | 2022/03/27 19:00 | Frances Tiafoe v Juan Manuel Cerundolo | 6-3,6-2 |
| ATP Miami | 2022/03/26 00:30 | Frances Tiafoe v Brandon Nakashima | 3-6,7-6,6-4 |
| ATP Indian Wells | 2022/03/16 03:00 | Andrey Rublev v Frances Tiafoe | 6-3,6-4 |
| ATP Indian Wells | 2022/03/14 00:00 | Brandon Nakashima v Frances Tiafoe | 4-6,4-6 |
| Australian Open | 2022/01/20 02:00 | Frances Tiafoe v Taylor Fritz | 4-6,3-6,6-7 |
Away History
| ATP Houston | 2022/04/08 01:55 | Steve Johnson v John Isner | 7-6,6-7,3-6 |
| ATP Miami | 2022/03/25 18:05 | John Isner v Hugo Gaston | 6-7,4-6 |
| ATP Indian Wells | 2022/03/16 21:30 | John Isner v Grigor Dimitrov | 3-6,6-7 |
| ATP Indian Wells | 2022/03/15 22:05 | Diego Schwartzman v John Isner | 5-7,3-6 |
| ATP Indian Wells | 2022/03/13 18:00 | Sam Querrey v John Isner | 6-7,6-7 |
| ATP Acapulco | 2022/02/24 00:00 | Cameron Norrie v John Isner | 6-7,6-3,6-4 |
| ATP Acapulco | 2022/02/22 00:00 | Fernando Verdasco v John Isner | 5-7,7-6,6-7 |
| ATP Dallas | 2022/02/12 22:00 | John Isner v Reilly Opelka | 6-7,6-7 |