[11] LA Chargers 16-22 SF 49ers [15] 2022-11-14 01:20
Stadium: Levi's Stadium Round: 1
Home Manager: Kyle Shanahan Away Manager: Brandon Staley
Head to Head
| NFL Preseason | 2021/08/22 23:30 | SF 49ers v LA Chargers | L | 15-10 |
| NFL Preseason | 2019/08/30 02:00 | LA Chargers v SF 49ers | W | 27-24 |
| NFL | 2018/09/30 20:25 | SF 49ers v LA Chargers | W | 27-29 |
| NFL Preseason | 2018/08/31 02:00 | LA Chargers v SF 49ers | W | 23-21 |
| NFL Preseason | 2017/09/01 02:00 | LA Chargers v SF 49ers | L | 13-23 |
| NFL Preseason | 2016/09/02 02:00 | LA Chargers v SF 49ers | L | 21-31 |
| NFL | 2014/12/21 01:25 | SF 49ers v LA Chargers | W | 35-38 |
Home History
| NFL | 2022/11/06 18:00 | LA Chargers v ATL Falcons | W | 20-17 |
| NFL | 2022/10/23 20:25 | SEA Seahawks v LA Chargers | L | 37-23 |
| NFL | 2022/10/18 00:15 | DEN Broncos v LA Chargers | W | 16-19 |
| NFL | 2022/10/09 17:00 | LA Chargers v CLE Browns | W | 30-28 |
| NFL | 2022/10/02 17:00 | LA Chargers v HOU Texans | W | 34-24 |
| NFL | 2022/09/25 20:05 | JAX Jaguars v LA Chargers | L | 38-10 |
| NFL | 2022/09/16 00:15 | LA Chargers v KC Chiefs | L | 24-27 |
| NFL | 2022/09/11 20:25 | LV Raiders v LA Chargers | W | 19-24 |
Away History
| NFL | 2022/10/30 20:25 | SF 49ers v LA Rams | W | 31-14 |
| NFL | 2022/10/23 20:25 | KC Chiefs v SF 49ers | L | 44-23 |
| NFL | 2022/10/16 17:00 | SF 49ers v ATL Falcons | L | 14-28 |
| NFL | 2022/10/09 20:05 | SF 49ers v CAR Panthers | W | 37-15 |
| NFL | 2022/10/04 00:15 | LA Rams v SF 49ers | W | 9-24 |
| NFL | 2022/09/26 00:20 | SF 49ers v DEN Broncos | L | 10-11 |
| NFL | 2022/09/18 20:05 | SEA Seahawks v SF 49ers | W | 7-27 |
| NFL | 2022/09/11 17:00 | SF 49ers v CHI Bears | L | 10-19 |