Head to Head
| NFL Preseason | 2021/08/13 23:00 | BUF Bills v DET Lions | W | 16-15 |
| NFL Preseason | 2019/08/24 00:00 | BUF Bills v DET Lions | W | 24-20 |
| NFL | 2018/12/16 18:00 | DET Lions v BUF Bills | W | 13-14 |
| NFL Preseason | 2017/08/31 23:00 | BUF Bills v DET Lions | W | 27-17 |
| NFL Preseason | 2016/09/01 23:30 | DET Lions v BUF Bills | L | 31-0 |
| NFL | 2014/10/05 17:00 | DET Lions v BUF Bills | W | 14-17 |
Home History
| NFL | 2022/11/20 18:00 | CLE Browns v BUF Bills | W | 23-31 |
| NFL | 2022/11/13 18:00 | MIN Vikings v BUF Bills | L | 33-30 |
| NFL | 2022/11/06 18:00 | BUF Bills v NY Jets | L | 17-20 |
| NFL | 2022/10/31 00:20 | GB Packers v BUF Bills | W | 17-27 |
| NFL | 2022/10/16 20:25 | BUF Bills v KC Chiefs | W | 24-20 |
| NFL | 2022/10/09 17:00 | PIT Steelers v BUF Bills | W | 3-38 |
| NFL | 2022/10/02 17:00 | BUF Bills v BAL Ravens | W | 23-20 |
| NFL | 2022/09/25 17:00 | BUF Bills v MIA Dolphins | L | 19-21 |
Away History
| NFL | 2022/11/20 18:00 | DET Lions v NY Giants | W | 31-18 |
| NFL | 2022/11/13 18:00 | DET Lions v CHI Bears | W | 31-30 |
| NFL | 2022/11/06 18:00 | GB Packers v DET Lions | W | 9-15 |
| NFL | 2022/10/30 17:00 | MIA Dolphins v DET Lions | L | 31-27 |
| NFL | 2022/10/23 17:00 | DET Lions v DAL Cowboys | L | 6-24 |
| NFL | 2022/10/09 17:00 | DET Lions v NE Patriots | L | 0-29 |
| NFL | 2022/10/02 17:00 | SEA Seahawks v DET Lions | L | 48-45 |
| NFL | 2022/09/25 17:00 | DET Lions v MIN Vikings | L | 24-28 |