Head to Head
| NFL Preseason | 2021/08/13 23:00 | BUF Bills v DET Lions | W | 16-15 |
| NFL Preseason | 2019/08/24 00:00 | BUF Bills v DET Lions | W | 24-20 |
| NFL | 2018/12/16 18:00 | DET Lions v BUF Bills | W | 13-14 |
| NFL Preseason | 2017/08/31 23:00 | BUF Bills v DET Lions | W | 27-17 |
| NFL Preseason | 2016/09/01 23:30 | DET Lions v BUF Bills | L | 31-0 |
| NFL | 2014/10/05 17:00 | DET Lions v BUF Bills | W | 14-17 |