[17] Tottenham 4-1 Southampton [16] 2022-08-06 14:00
Stadium: Tottenham Hotspur Stadium Round: 1
Referee: Andre Marriner Home Manager: Antonio Conte Away Manager: Ralph Hasenhuttl
Head to Head
| England Premier League | 2022/02/09 19:45 | Tottenham v Southampton | L | 2-3 |
| England Premier League | 2021/12/28 15:00 | Southampton v Tottenham | D | 1-1 |
| England Premier League | 2021/04/21 17:00 | Tottenham v Southampton | W | 2-1 |
| England Premier League | 2020/09/20 11:00 | Southampton v Tottenham | W | 2-5 |
| England FA Cup | 2020/02/05 19:45 | Tottenham v Southampton | W | 3-2 |
| England FA Cup | 2020/01/25 15:00 | Southampton v Tottenham | D | 1-1 |
| England Premier League | 2020/01/01 15:00 | Southampton v Tottenham | L | 1-0 |
| England Premier League | 2019/09/28 14:00 | Tottenham v Southampton | W | 2-1 |
Home History
| Elite Club Friendlies | 2022/07/30 18:15 | Tottenham v Roma | L | 0-1 |
| Elite Club Friendlies | 2022/07/23 14:00 | Rangers v Tottenham | W | 1-2 |
| Elite Club Friendlies | 2022/07/16 11:00 | Tottenham v Sevilla | D | 1-1 |
| Elite Club Friendlies | 2022/07/13 11:00 | K League All Stars v Tottenham | W | 3-6 |
| England Premier League | 2022/05/22 15:00 | Norwich v Tottenham | W | 0-5 |
| England Premier League | 2022/05/15 11:00 | Tottenham v Burnley | W | 1-0 |
| England Premier League | 2022/05/12 18:45 | Tottenham v Arsenal | W | 3-0 |
| England Premier League | 2022/05/07 18:45 | Liverpool v Tottenham | D | 1-1 |
Away History
| Elite Club Friendlies | 2022/07/30 14:00 | Southampton v Villarreal | L | 1-2 |
| Elite Club Friendlies | 2022/07/27 18:45 | Southampton v Monaco | W | 3-1 |
| Elite Club Friendlies | 2022/07/18 17:00 | Austria Klagenfurt v Southampton | D | 0-0 |
| Elite Club Friendlies | 2022/07/16 12:00 | RB Leipzig v Southampton | L | 3-1 |
| England Premier League | 2022/05/22 15:00 | Leicester v Southampton | L | 4-1 |
| England Premier League | 2022/05/17 18:45 | Southampton v Liverpool | L | 1-2 |
| England Premier League | 2022/05/07 14:00 | Brentford v Southampton | L | 3-0 |
| England Premier League | 2022/04/30 14:00 | Southampton v Crystal Palace | L | 1-2 |