[5] Mainz 0-3 Bayer Leverkusen [17] 2022-08-27 13:30
Stadium: Mewa Arena Round: 4
Referee: Christian Dingert Home Manager: Bo Svensson Away Manager: Gerardo Seoane
Head to Head
| Germany Bundesliga I | 2022/02/18 19:30 | Mainz v Bayer Leverkusen | W | 3-2 |
| Germany Bundesliga I | 2021/09/25 13:30 | Bayer Leverkusen v Mainz | L | 1-0 |
| Germany Bundesliga I | 2021/02/13 14:30 | Bayer Leverkusen v Mainz | D | 2-2 |
| Germany Bundesliga I | 2020/10/17 13:30 | Mainz v Bayer Leverkusen | L | 0-1 |
| Germany Bundesliga I | 2020/06/27 13:30 | Bayer Leverkusen v Mainz | L | 1-0 |
| Germany Bundesliga I | 2019/12/21 14:30 | Mainz v Bayer Leverkusen | L | 0-1 |
| Germany Bundesliga I | 2019/02/08 19:30 | Mainz v Bayer Leverkusen | L | 1-5 |
| Germany Bundesliga I | 2018/09/23 13:30 | Bayer Leverkusen v Mainz | L | 1-0 |
Home History
| Germany Bundesliga I | 2022/08/20 13:30 | Augsburg v Mainz | W | 1-2 |
| Germany Bundesliga I | 2022/08/14 13:30 | Mainz v Union Berlin | D | 0-0 |
| Germany Bundesliga I | 2022/08/06 13:30 | Bochum v Mainz | W | 1-2 |
| Germany DFB Pokal | 2022/07/31 16:00 | Erzgebirge Aue v Mainz | W | 0-3 |
| Club Friendly List | 2022/07/23 15:00 | Mainz v Athletic Bilbao | D | 1-1 |
| Elite Club Friendlies | 2022/07/18 14:00 | Mainz v Newcastle | W | 1-0 |
| Europe Friendlies | 2022/07/15 18:15 | Besiktas v Mainz | L | 1-0 |
| Germany Bundesliga I | 2022/05/14 13:30 | Mainz v Eintracht Frankfurt | D | 2-2 |
Away History
| Germany Bundesliga I | 2022/08/20 13:30 | Bayer Leverkusen v TSG Hoffenheim | L | 0-3 |
| Germany Bundesliga I | 2022/08/13 13:30 | Bayer Leverkusen v Augsburg | L | 1-2 |
| Germany Bundesliga I | 2022/08/06 16:30 | Borussia Dortmund v Bayer Leverkusen | L | 1-0 |
| Germany DFB Pokal | 2022/07/30 13:31 | Elversberg v Bayer Leverkusen | L | 4-3 |
| Elite Club Friendlies | 2022/07/21 16:00 | Bayer Leverkusen v Udinese | W | 2-1 |
| Europe Friendlies | 2022/07/17 15:00 | Bayer Leverkusen v Panathinaikos | D | 0-0 |
| Europe Friendlies | 2022/07/09 13:30 | Bayer Leverkusen v MSV Duisburg | W | 6-1 |
| World Club Friendlies | 2022/05/18 00:30 | Toluca v Bayer Leverkusen | L | 1-0 |