[5] Mainz 0-3 Bayer Leverkusen [17] 2022-08-27 13:30
Stadium: Mewa Arena Round: 4
Referee: Christian Dingert Home Manager: Bo Svensson Away Manager: Gerardo Seoane
Head to Head
| Germany Bundesliga I | 2022/02/18 19:30 | Mainz v Bayer Leverkusen | W | 3-2 |
| Germany Bundesliga I | 2021/09/25 13:30 | Bayer Leverkusen v Mainz | L | 1-0 |
| Germany Bundesliga I | 2021/02/13 14:30 | Bayer Leverkusen v Mainz | D | 2-2 |
| Germany Bundesliga I | 2020/10/17 13:30 | Mainz v Bayer Leverkusen | L | 0-1 |
| Germany Bundesliga I | 2020/06/27 13:30 | Bayer Leverkusen v Mainz | L | 1-0 |
| Germany Bundesliga I | 2019/12/21 14:30 | Mainz v Bayer Leverkusen | L | 0-1 |
| Germany Bundesliga I | 2019/02/08 19:30 | Mainz v Bayer Leverkusen | L | 1-5 |
| Germany Bundesliga I | 2018/09/23 13:30 | Bayer Leverkusen v Mainz | L | 1-0 |
| Germany Bundesliga I | 2018/01/28 14:30 | Bayer Leverkusen v Mainz | L | 2-0 |
| Germany Bundesliga I | 2017/09/09 13:30 | Mainz v Bayer Leverkusen | W | 3-1 |
| Germany Bundesliga I | 2017/02/25 14:30 | Bayer Leverkusen v Mainz | W | 0-2 |
| Germany Bundesliga I | 2016/09/24 13:30 | Mainz v Bayer Leverkusen | L | 2-3 |
| Germany Bundesliga I | 2016/02/28 16:30 | Mainz v Bayer Leverkusen | W | 3-1 |
| Germany Bundesliga I | 2015/09/23 18:00 | Bayer Leverkusen v Mainz | L | 1-0 |
| Germany Bundesliga I | 2015/04/11 13:30 | Mainz v Bayer Leverkusen | L | 2-3 |
| Germany Bundesliga I | 2014/11/08 14:30 | Bayer Leverkusen v Mainz | D | 0-0 |