Stadium: Memorial Stadium (Terre Haute) Round: 1
Home Manager: Curt Mallory Away Manager: Chris Willis
| NCAAF | 2021/11/20 18:00 | North Alabama v Hampton | W | 35-27 |
| NCAAF | 2021/11/13 20:00 | Kennesaw State v North Alabama | L | 28-24 |
| NCAAF | 2021/11/06 17:00 | North Alabama v Monmouth | L | 33-45 |
| NCAAF | 2021/10/23 19:00 | Charleston Southern v North Alabama | W | 22-45 |
| NCAAF | 2021/10/16 23:00 | Robert Morris v North Alabama | W | 31-42 |
| NCAAF | 2021/10/09 17:00 | North Alabama v North Carolina A&T | L | 34-38 |
| NCAAF | 2021/10/02 23:00 | Campbell v North Alabama | L | 48-31 |
| NCAAF | 2021/09/25 20:00 | North Alabama v Nicholls State | L | 14-31 |
| NCAAF | 2021/11/20 18:00 | Indiana State v Illinois State | W | 15-10 |
| NCAAF | 2021/11/13 18:00 | SO Illinois v Indiana State | L | 47-21 |
| NCAAF | 2021/10/30 19:30 | Indiana State v North Dakota State | L | 2-44 |
| NCAAF | 2021/10/23 17:00 | Youngstown State v Indiana State | W | 17-28 |
| NCAAF | 2021/10/16 19:00 | Indiana State v Missouri St | L | 7-37 |
| NCAAF | 2021/10/09 17:00 | Western Illinois v Indiana State | W | 27-37 |
| NCAAF | 2021/10/02 19:00 | Indiana State v South Dakota | L | 10-38 |
| NCAAF | 2021/09/25 17:00 | South Dakota State v Indiana State | L | 44-0 |