Stadium: Robert W. Plaster Stadium Round: 1
Home Manager: Bobby Petrino Away Manager: Myers Hendrickson
| NCAAF | 2021/02/27 18:00 | Missouri St v Western Illinois | L | 30-24 |
| NCAAF | 2019/10/05 20:00 | Missouri St v Western Illinois | L | 37-31 |
| NCAAF | 2018/10/20 19:00 | Missouri St v Western Illinois | W | 14-31 |
| NCAAF | 2017/10/14 20:00 | Western Illinois v Missouri St | W | 49-30 |
| NCAAF | 2022/10/22 20:00 | Youngstown State v Western Illinois | L | 28-27 |
| NCAAF | 2022/10/15 19:00 | Western Illinois v SO Illinois | L | 7-30 |
| NCAAF | 2022/10/01 19:00 | Western Illinois v South Dakota State | L | 10-34 |
| NCAAF | 2022/09/24 20:00 | Northern Iowa v Western Illinois | L | 52-17 |
| NCAAF | 2022/09/17 20:00 | Southern Utah v Western Illinois | L | 17-10 |
| NCAAF | 2022/09/10 16:00 | Western Illinois v Minnesota | L | 10-62 |
| NCAAF | 2022/09/01 23:30 | Western Illinois v Tennessee Martin | L | 25-42 |
| NCAAF | 2021/11/20 19:00 | Western Illinois v Northern Iowa | L | 3-41 |
| NCAAF | 2022/10/22 21:00 | Missouri St v Northern Iowa | L | 20-41 |
| NCAAF | 2022/10/08 19:00 | SO Illinois v Missouri St | L | 38-21 |
| NCAAF | 2022/10/01 17:00 | Missouri St v North Dakota | L | 31-48 |
| NCAAF | 2022/09/24 19:00 | South Dakota State v Missouri St | L | 28-14 |
| NCAAF | 2022/09/17 23:00 | Missouri St v Arkansas | L | 27-38 |
| NCAAF | 2022/09/09 00:00 | Tennessee Martin v Missouri St | W | 30-35 |
| NCAAF | 2022/09/02 00:00 | Missouri St v Central Arkansas | W | 27-14 |
| NCAAF | 2021/11/27 21:00 | Tennessee Martin v Missouri St | L | 32-31 |