Stadium: Dana J. Dykhouse Stadium Round: 1
Home Manager: John Stiegelmeier Away Manager: Myers Hendrickson
| NCAAF | 2021/10/16 17:00 | South Dakota State v Western Illinois | L | 41-17 |
| NCAAF | 2021/03/06 20:00 | Western Illinois v South Dakota State | L | 10-45 |
| NCAAF | 2017/10/28 18:00 | Western Illinois v South Dakota State | L | 24-52 |
| NCAAF | 2022/09/24 20:00 | Northern Iowa v Western Illinois | L | 52-17 |
| NCAAF | 2022/09/17 20:00 | Southern Utah v Western Illinois | L | 17-10 |
| NCAAF | 2022/09/10 16:00 | Western Illinois v Minnesota | L | 10-62 |
| NCAAF | 2022/09/01 23:30 | Western Illinois v Tennessee Martin | L | 25-42 |
| NCAAF | 2021/11/20 19:00 | Western Illinois v Northern Iowa | L | 3-41 |
| NCAAF | 2021/11/06 17:00 | South Dakota v Western Illinois | L | 42-21 |
| NCAAF | 2021/10/30 20:00 | Illinois State v Western Illinois | W | 31-38 |
| NCAAF | 2021/10/23 19:00 | Western Illinois v North Dakota | L | 10-34 |
| NCAAF | 2022/09/24 19:00 | South Dakota State v Missouri St | W | 28-14 |
| NCAAF | 2022/09/17 23:00 | Butler v South Dakota State | W | 17-45 |
| NCAAF | 2022/09/10 23:00 | UC Davis v South Dakota State | W | 22-24 |
| NCAAF | 2022/09/03 16:00 | South Dakota State v Iowa | L | 3-7 |
| NCAAF | 2021/12/18 19:00 | South Dakota State v Montana State | L | 17-31 |
| NCAAF | 2021/12/11 19:00 | South Dakota State v Villanova | W | 35-21 |
| NCAAF | 2021/12/05 02:00 | South Dakota State v CS Sacramento | W | 24-19 |
| NCAAF | 2021/11/27 20:00 | UC Davis v South Dakota State | W | 24-56 |