Southern Illinois 24-27 South Dakota 2022-10-22 19:00
Stadium: DakotaDome Round: 1
Home Manager: Bob Nielson Away Manager: Nick Hill
Head to Head
| NCAAF | 2021/11/27 23:00 | SO Illinois v South Dakota | W | 22-10 |
| NCAAF | 2019/10/26 21:00 | SO Illinois v South Dakota | W | 48-28 |
| NCAAF | 2018/09/29 23:00 | South Dakota v SO Illinois | L | 31-24 |
| NCAAF | 2017/10/28 20:00 | South Dakota v SO Illinois | L | 42-0 |
Home History
| NCAAF | 2022/10/15 19:00 | Western Illinois v SO Illinois | W | 7-30 |
| NCAAF | 2022/10/08 19:00 | SO Illinois v Missouri St | W | 38-21 |
| NCAAF | 2022/10/01 23:30 | SO Illinois v Illinois State | W | 19-14 |
| NCAAF | 2022/09/24 19:00 | North Dakota v SO Illinois | W | 17-34 |
| NCAAF | 2022/09/17 16:00 | SO Illinois v Northwestern | W | 31-24 |
| NCAAF | 2022/09/10 23:00 | SE Missouri St v SO Illinois | L | 34-31 |
| NCAAF | 2022/09/03 23:00 | SO Illinois v Incarnate Word | L | 29-64 |
| NCAAF | 2021/12/04 20:30 | SO Illinois v North Dakota State | L | 7-38 |
Away History
| NCAAF | 2022/10/15 19:00 | South Dakota v Illinois State | L | 10-12 |
| NCAAF | 2022/10/08 19:00 | South Dakota v South Dakota State | L | 3-28 |
| NCAAF | 2022/09/24 18:00 | North Dakota State v South Dakota | L | 34-17 |
| NCAAF | 2022/09/17 18:00 | Cal Poly v South Dakota | W | 21-38 |
| NCAAF | 2022/09/10 19:30 | South Dakota v Montana | L | 7-24 |
| NCAAF | 2022/09/03 23:00 | South Dakota v Kansas State | L | 0-34 |
| NCAAF | 2021/11/27 23:00 | SO Illinois v South Dakota | L | 22-10 |
| NCAAF | 2021/11/20 20:30 | South Dakota v North Dakota State | L | 24-52 |