Stadium: Hancock Stadium Round: 1
Home Manager: Brock Spack Away Manager: Chris Wilkerson
| NCAAF | 2021/09/18 23:00 | Illinois State v Eastern Illinois | L | 31-24 |
| NCAAF | 2019/09/14 19:00 | Illinois State v Eastern Illinois | L | 21-3 |
| NCAAF | 2018/09/08 23:30 | Eastern Illinois v Illinois State | L | 10-48 |
| NCAAF | 2017/09/16 19:00 | Eastern Illinois v Illinois State | L | 13-44 |
| NCAAF | 2022/09/10 23:00 | Tennessee Chattanooga v Eastern Illinois | L | 38-20 |
| NCAAF | 2022/09/02 00:00 | Eastern Illinois v Northern Illinois | L | 27-34 |
| NCAAF | 2021/11/20 18:00 | Murray State v Eastern Illinois | L | 20-13 |
| NCAAF | 2021/11/06 19:00 | Eastern Illinois v Austin Peay | L | 26-42 |
| NCAAF | 2021/10/30 18:00 | Eastern Illinois v SE Missouri St | L | 15-38 |
| NCAAF | 2021/10/23 19:00 | Tennessee State v Eastern Illinois | L | 28-0 |
| NCAAF | 2021/10/16 19:00 | Tennessee Martin v Eastern Illinois | L | 28-17 |
| NCAAF | 2021/10/02 21:00 | Eastern Illinois v Murray State | L | 6-22 |
| NCAAF | 2022/09/10 23:30 | Valparaiso v Illinois State | W | 21-28 |
| NCAAF | 2022/09/03 23:00 | Illinois State v Wisconsin | L | 0-38 |
| NCAAF | 2021/11/20 18:00 | Indiana State v Illinois State | L | 15-10 |
| NCAAF | 2021/11/13 20:00 | Illinois State v North Dakota | L | 7-14 |
| NCAAF | 2021/11/06 17:00 | Northern Iowa v Illinois State | W | 10-17 |
| NCAAF | 2021/10/30 20:00 | Illinois State v Western Illinois | L | 31-38 |
| NCAAF | 2021/10/23 18:00 | Illinois State v South Dakota | W | 20-14 |
| NCAAF | 2021/10/16 19:00 | North Dakota State v Illinois State | L | 20-0 |