Stadium: Hancock Stadium Round: 1
Home Manager: Brock Spack Away Manager: Myers Hendrickson
| NCAAF | 2021/10/30 20:00 | Illinois State v Western Illinois | W | 31-38 |
| NCAAF | 2021/03/20 16:00 | Western Illinois v Illinois State | L | 18-26 |
| NCAAF | 2019/10/19 18:00 | Illinois State v Western Illinois | L | 28-14 |
| NCAAF | 2018/10/06 19:00 | Western Illinois v Illinois State | L | 16-33 |
| NCAAF | 2017/11/04 17:00 | Illinois State v Western Illinois | W | 14-31 |
| NCAAF | 2015/12/05 19:00 | Illinois State v Western Illinois | L | 36-19 |
| NCAAF | 2022/11/12 19:00 | Indiana State v Western Illinois | L | 21-0 |
| NCAAF | 2022/11/05 18:00 | North Dakota State v Western Illinois | L | 56-17 |
| NCAAF | 2022/10/29 19:00 | Western Illinois v Missouri St | L | 14-64 |
| NCAAF | 2022/10/22 20:00 | Youngstown State v Western Illinois | L | 28-27 |
| NCAAF | 2022/10/15 19:00 | Western Illinois v SO Illinois | L | 7-30 |
| NCAAF | 2022/10/01 19:00 | Western Illinois v South Dakota State | L | 10-34 |
| NCAAF | 2022/09/24 20:00 | Northern Iowa v Western Illinois | L | 52-17 |
| NCAAF | 2022/09/17 20:00 | Southern Utah v Western Illinois | L | 17-10 |
| NCAAF | 2022/11/12 20:00 | Illinois State v South Dakota State | L | 7-31 |
| NCAAF | 2022/11/05 19:00 | Youngstown State v Illinois State | L | 19-17 |
| NCAAF | 2022/10/29 19:30 | Illinois State v North Dakota State | L | 7-24 |
| NCAAF | 2022/10/22 17:00 | Illinois State v Indiana State | W | 27-21 |
| NCAAF | 2022/10/15 19:00 | South Dakota v Illinois State | W | 10-12 |
| NCAAF | 2022/10/08 21:00 | Illinois State v Northern Iowa | W | 23-21 |
| NCAAF | 2022/10/01 23:30 | SO Illinois v Illinois State | L | 19-14 |
| NCAAF | 2022/09/17 23:30 | Eastern Illinois v Illinois State | W | 7-35 |