Stadium: Dana J. Dykhouse Stadium Round: 1
Home Manager: John Stiegelmeier Away Manager: Curt Mallory
| NCAAF | 2021/09/25 17:00 | South Dakota State v Indiana State | L | 44-0 |
| NCAAF | 2019/10/19 17:00 | South Dakota State v Indiana State | L | 42-23 |
| NCAAF | 2018/10/06 23:00 | Indiana State v South Dakota State | L | 51-54 |
| NCAAF | 2022/10/22 17:00 | Illinois State v Indiana State | L | 27-21 |
| NCAAF | 2022/10/15 18:00 | Indiana State v Youngstown State | L | 42-48 |
| NCAAF | 2022/10/08 17:00 | North Dakota State v Indiana State | L | 31-26 |
| NCAAF | 2022/10/01 21:00 | Indiana State v Northern Iowa | L | 14-20 |
| NCAAF | 2022/09/17 17:00 | Montana v Indiana State | L | 49-14 |
| NCAAF | 2022/09/10 20:00 | Indiana State v Purdue | L | 0-56 |
| NCAAF | 2022/09/01 22:00 | North Alabama v Indiana State | W | 14-17 |
| NCAAF | 2021/11/20 18:00 | Indiana State v Illinois State | W | 15-10 |
| NCAAF | 2022/10/22 20:00 | South Dakota State v North Dakota | W | 49-35 |
| NCAAF | 2022/10/15 19:30 | South Dakota State v North Dakota State | W | 23-21 |
| NCAAF | 2022/10/08 19:00 | South Dakota v South Dakota State | W | 3-28 |
| NCAAF | 2022/10/01 19:00 | Western Illinois v South Dakota State | W | 10-34 |
| NCAAF | 2022/09/24 19:00 | South Dakota State v Missouri St | W | 28-14 |
| NCAAF | 2022/09/17 23:00 | Butler v South Dakota State | W | 17-45 |
| NCAAF | 2022/09/10 23:00 | UC Davis v South Dakota State | W | 22-24 |
| NCAAF | 2022/09/03 16:00 | South Dakota State v Iowa | L | 3-7 |