Stadium: William B. Greene Jr. Stadium Round: 1
Home Manager: George Quarles Away Manager: Chris Hatcher
| NCAAF | 2021/09/25 19:00 | East Tennessee State v Samford | L | 55-48 |
| NCAAF | 2021/02/20 18:00 | Samford v East Tennessee State | L | 17-24 |
| NCAAF | 2019/10/26 17:00 | East Tennessee State v Samford | W | 17-24 |
| NCAAF FCS | 2018/11/17 18:00 | Samford v East Tennessee State | W | 38-27 |
| NCAAF | 2017/11/11 20:00 | Samford v East Tennessee State | W | 42-7 |
| NCAAF | 2022/10/08 17:00 | Wofford v Samford | W | 14-28 |
| NCAAF | 2022/10/01 18:00 | Samford v Furman | W | 34-27 |
| NCAAF | 2022/09/24 19:00 | Western Carolina v Samford | W | 12-35 |
| NCAAF | 2022/09/17 23:00 | Samford v Tennessee Tech | W | 33-28 |
| NCAAF | 2022/09/10 20:00 | Samford v Georgia | L | 0-33 |
| NCAAF | 2022/09/01 23:00 | Kennesaw State v Samford | W | 17-27 |
| NCAAF | 2021/11/20 18:00 | Furman v Samford | L | 41-34 |
| NCAAF | 2021/11/13 17:00 | Samford v Florida | L | 52-70 |
| NCAAF | 2022/10/15 20:00 | East Tennessee State v Mercer | L | 33-55 |
| NCAAF | 2022/10/08 17:30 | East Tennessee State v VMI | W | 44-21 |
| NCAAF | 2022/10/01 19:00 | Tennessee Chattanooga v East Tennessee State | L | 24-16 |
| NCAAF | 2022/09/24 16:00 | East Tennessee State v Robert Morris | W | 45-3 |
| NCAAF | 2022/09/17 23:30 | Furman v East Tennessee State | L | 27-14 |
| NCAAF | 2022/09/10 20:00 | East Tennessee State v The Citadel | L | 17-20 |
| NCAAF | 2022/09/01 23:30 | East Tennessee State v Mars Hill Lions | W | 44-7 |
| NCAAF | 2021/12/11 17:00 | East Tennessee State v North Dakota State | L | 3-27 |